Lentigo maligna and malignant melanoma in situ, lentigo maligna type

Thomas J. Flotte, Martin C. Mihm

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Some authors have considered lentigo maligna to be an atypical melanocytic proliferation, whereas others have considered it to be melanoma in situ. We reviewed 50 cases of lentigo maligna. We have identified two subsets of lesions. The first has atypical melanocytic hyperplasia, which we postulate to be correctly designated lentigo maligna. The second subset has the following features in addition to the melanocytic hyperplasia: individual and nests of cells at varying layers of the epidermis, confluence of the melanocytes replacing the basilar region, uniformity of the cytological atypia, and nesting of uniformly atypical melanocytes. These lesions we designate as malignant melanoma in situ, lentigo maligna type. We are proposing that the lesions that have been termed lentigo maligna represent a spectrum of atypia and that the application of some of the traditional features for the diagnosis melanoma may permit the segregation of more and less aggressive lesions.

Original languageEnglish (US)
Pages (from-to)533-536
Number of pages4
JournalHuman Pathology
Issue number5
StatePublished - Jan 1 1999


  • Lentigo maligna
  • Melanoma in situ
  • Pagetoid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


Dive into the research topics of 'Lentigo maligna and malignant melanoma in situ, lentigo maligna type'. Together they form a unique fingerprint.

Cite this