TY - JOUR
T1 - Left Ventricular Systolic Dysfunction and Cardiovascular Outcomes in Tetralogy of Fallot
T2 - Systematic Review and Meta-analysis
AU - Egbe, Alexander C.
AU - Adigun, Rosalyn
AU - Anand, Vidhu
AU - West, Collin P.
AU - Montori, Victor M.
AU - Murad, Hassan M.
AU - Akintoye, Emmanuel
AU - Osman, Karim
AU - Connolly, Heidi M.
N1 - Publisher Copyright:
© 2019 Canadian Cardiovascular Society
PY - 2019/12
Y1 - 2019/12
N2 - Background: Although there are robust data about the pathophysiology and prognostic implications of left ventricular (LV) systolic dysfunction in patients with acquired heart disease, similar prognostic data about LV systolic dysfunction are sparse in the tetralogy of Fallot (TOF) population. The purpose of this study was to perform a meta-analysis of all studies that assessed the relationship between LV ejection fraction (LVEF) and cardiovascular adverse events (CAEs) defined as death, aborted sudden death, or sustained ventricular tachycardia. Methods: We used random-effects models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Of the 1,809 citations, 7 studies with 2,854 patients (age 28 ± 4 years) were included. During 5.6 ± 3.4 years' follow-up, there were 82 deaths, 17 aborted sudden cardiac deaths, and 56 sustained ventricular tachycardia events. Overall, CAEs occurred in 5.1% (144 patients). As a continuous variable, LVEF was a predictor of CAE (HR 1.29, 95% CI, 1.09-1.53, P = 0.001) per 5% decrease in LVEF. Similarly, LVEF < 40% was also a predictor of CAE (HR 3.22, 95% CI, 2.16-4.80, P < 0.001). Conclusions: LV systolic dysfunction was an independent predictor of CAE, and we observed a 30% increase in the risk of CAE for every 5% decrease in LVEF, and a 3-fold increase in the risk of CAE in patients with LVEF <40% compared with other patients. These findings underscore the importance of incorporating LV systolic function in clinical risk stratification of patients with TOF and the need to explore new treatment options to address this problem.
AB - Background: Although there are robust data about the pathophysiology and prognostic implications of left ventricular (LV) systolic dysfunction in patients with acquired heart disease, similar prognostic data about LV systolic dysfunction are sparse in the tetralogy of Fallot (TOF) population. The purpose of this study was to perform a meta-analysis of all studies that assessed the relationship between LV ejection fraction (LVEF) and cardiovascular adverse events (CAEs) defined as death, aborted sudden death, or sustained ventricular tachycardia. Methods: We used random-effects models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Of the 1,809 citations, 7 studies with 2,854 patients (age 28 ± 4 years) were included. During 5.6 ± 3.4 years' follow-up, there were 82 deaths, 17 aborted sudden cardiac deaths, and 56 sustained ventricular tachycardia events. Overall, CAEs occurred in 5.1% (144 patients). As a continuous variable, LVEF was a predictor of CAE (HR 1.29, 95% CI, 1.09-1.53, P = 0.001) per 5% decrease in LVEF. Similarly, LVEF < 40% was also a predictor of CAE (HR 3.22, 95% CI, 2.16-4.80, P < 0.001). Conclusions: LV systolic dysfunction was an independent predictor of CAE, and we observed a 30% increase in the risk of CAE for every 5% decrease in LVEF, and a 3-fold increase in the risk of CAE in patients with LVEF <40% compared with other patients. These findings underscore the importance of incorporating LV systolic function in clinical risk stratification of patients with TOF and the need to explore new treatment options to address this problem.
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U2 - 10.1016/j.cjca.2019.07.634
DO - 10.1016/j.cjca.2019.07.634
M3 - Review article
C2 - 31732195
AN - SCOPUS:85075458615
SN - 0828-282X
VL - 35
SP - 1784
EP - 1790
JO - Canadian Journal of Cardiology
JF - Canadian Journal of Cardiology
IS - 12
ER -