Left Ventricular Function and C-Reactive Protein Levels in Acute Myocardial Infarction

Adelaide M. Arruda-Olson, Maurice Enriquez-Sarano, Francesca Bursi, Susan A. Weston, Allan S. Jaffe, Jill M. Killian, Véronique L. Roger

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

To examine left ventricular (LV) function in patients after acute myocardial infarction (AMI) and assess its relation to C-reactive protein (CRP) as a measure of the early inflammatory response. We measured the CRP levels early after AMI and correlated them with the early structural and functional cardiac alterations. From November 2002 to December 2007, we prospectively enrolled community subjects who had experienced an AMI, as defined by standardized criteria, measured the CRP level, and obtained an echocardiogram. The study consisted of 514 patients (mean age 67 ± 15 years, 59% men). CRP was measured early after symptom onset (median 6.1 hours; twenty-fifth to seventy-fifth percentile 2.2 to 11.1). The median CRP level was 4.8 mg/L (twenty-fifth to seventy-fifth percentile 1.8 to 24). The echocardiograms were obtained at a median of 1 day after AMI. The wall motion score index, LV ejection fraction, and LV diameter were similar across the CRP tertiles (all p >0.05). Greater CRP levels were associated with the presence of moderate or severe diastolic dysfunction (p = 0.002) and moderate or severe mitral regurgitation (p <0.001). The association with moderate or severe mitral regurgitation was independent of the clinical characteristics and ST-segment elevation status. In conclusion, at the initial phase of AMI, CRP elevation was associated with the presence and severity of mitral regurgitation and diastolic dysfunction. This suggests that inflammation is related to the ventricular remodeling processes, independently of LV systolic function.

Original languageEnglish (US)
Pages (from-to)917-921
Number of pages5
JournalAmerican Journal of Cardiology
Volume105
Issue number7
DOIs
StatePublished - Apr 1 2010

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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