Left ventricular function after noninvasive cardiac ablation using proton beam therapy in a porcine model

Stephan Hohmann, Amanda J. Deisher, Atsushi Suzuki, Hiroki Konishi, Maryam E. Rettmann, Kenneth W. Merrell, Jon J. Kruse, Laura K. Newman, Kay D. Parker, Kristi H. Monahan, Robert L. Foote, Michael G. Herman, Douglas L. Packer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Noninvasive cardiac ablation of ventricular tachycardia (VT) using radiotherapy has recently gained interest among electrophysiologists. The effects of left ventricular (LV) ablative radiation treatment on global LV function and volumes are unknown. Objective: The purpose of this study was to investigate the effects of noninvasive ablation on LV function over time. Methods: Twenty domestic swine underwent proton beam treatment of LV sites in a dose-finding design and were followed for up to 40 weeks by cardiac magnetic resonance imaging at 4-week intervals. Doses investigated were either 40 Gy at 1 site (n = 8) or 30 Gy at 2 sites (n = 4) in the low-dose group and 40 Gy at 3 sites (n = 8) in the high-dose group. Results: LV mean dose (13.2 ± 1.8 Gy vs 4.6 ± 1.8 Gy) and the volume receiving at least 20 Gy (V20Gy) (24.7% ± 4.8% vs 6.4% ± 3.0%) differed significantly between groups. Dose-dependent effects on left ventricular ejection fraction (LVEF) and LV end-diastolic volume became manifest about 3 months after treatment. LVEF decline was correlated to mean dose (correlation coefficient ρ = –0.69; P = .008) and V20Gy (ρ = –0.66; P = .01), as was LV dilation (ρ = 0.72; P = .005; and ρ = 0.75, P = .003 respectively). Conclusion: Possible adverse effects on LV function, seen about 3 months after treatment, are dose dependent. Therefore, precise target definition and focused energy delivery are paramount in catheter-free ablation.

Original languageEnglish (US)
Pages (from-to)1710-1719
Number of pages10
JournalHeart rhythm
Volume16
Issue number11
DOIs
StatePublished - Nov 2019

Fingerprint

Proton Therapy
Left Ventricular Function
Swine
Stroke Volume
Catheter Ablation
Therapeutics
Ventricular Tachycardia
Protons
Dilatation
Radiotherapy
Magnetic Resonance Imaging
Radiation

Keywords

  • Cardiac function
  • Catheter-free ablation
  • Proton beam therapy
  • Radiation therapy
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Left ventricular function after noninvasive cardiac ablation using proton beam therapy in a porcine model. / Hohmann, Stephan; Deisher, Amanda J.; Suzuki, Atsushi; Konishi, Hiroki; Rettmann, Maryam E.; Merrell, Kenneth W.; Kruse, Jon J.; Newman, Laura K.; Parker, Kay D.; Monahan, Kristi H.; Foote, Robert L.; Herman, Michael G.; Packer, Douglas L.

In: Heart rhythm, Vol. 16, No. 11, 11.2019, p. 1710-1719.

Research output: Contribution to journalArticle

Hohmann, S, Deisher, AJ, Suzuki, A, Konishi, H, Rettmann, ME, Merrell, KW, Kruse, JJ, Newman, LK, Parker, KD, Monahan, KH, Foote, RL, Herman, MG & Packer, DL 2019, 'Left ventricular function after noninvasive cardiac ablation using proton beam therapy in a porcine model', Heart rhythm, vol. 16, no. 11, pp. 1710-1719. https://doi.org/10.1016/j.hrthm.2019.04.030
Hohmann, Stephan ; Deisher, Amanda J. ; Suzuki, Atsushi ; Konishi, Hiroki ; Rettmann, Maryam E. ; Merrell, Kenneth W. ; Kruse, Jon J. ; Newman, Laura K. ; Parker, Kay D. ; Monahan, Kristi H. ; Foote, Robert L. ; Herman, Michael G. ; Packer, Douglas L. / Left ventricular function after noninvasive cardiac ablation using proton beam therapy in a porcine model. In: Heart rhythm. 2019 ; Vol. 16, No. 11. pp. 1710-1719.
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abstract = "Background: Noninvasive cardiac ablation of ventricular tachycardia (VT) using radiotherapy has recently gained interest among electrophysiologists. The effects of left ventricular (LV) ablative radiation treatment on global LV function and volumes are unknown. Objective: The purpose of this study was to investigate the effects of noninvasive ablation on LV function over time. Methods: Twenty domestic swine underwent proton beam treatment of LV sites in a dose-finding design and were followed for up to 40 weeks by cardiac magnetic resonance imaging at 4-week intervals. Doses investigated were either 40 Gy at 1 site (n = 8) or 30 Gy at 2 sites (n = 4) in the low-dose group and 40 Gy at 3 sites (n = 8) in the high-dose group. Results: LV mean dose (13.2 ± 1.8 Gy vs 4.6 ± 1.8 Gy) and the volume receiving at least 20 Gy (V20Gy) (24.7{\%} ± 4.8{\%} vs 6.4{\%} ± 3.0{\%}) differed significantly between groups. Dose-dependent effects on left ventricular ejection fraction (LVEF) and LV end-diastolic volume became manifest about 3 months after treatment. LVEF decline was correlated to mean dose (correlation coefficient ρ = –0.69; P = .008) and V20Gy (ρ = –0.66; P = .01), as was LV dilation (ρ = 0.72; P = .005; and ρ = 0.75, P = .003 respectively). Conclusion: Possible adverse effects on LV function, seen about 3 months after treatment, are dose dependent. Therefore, precise target definition and focused energy delivery are paramount in catheter-free ablation.",
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T1 - Left ventricular function after noninvasive cardiac ablation using proton beam therapy in a porcine model

AU - Hohmann, Stephan

AU - Deisher, Amanda J.

AU - Suzuki, Atsushi

AU - Konishi, Hiroki

AU - Rettmann, Maryam E.

AU - Merrell, Kenneth W.

AU - Kruse, Jon J.

AU - Newman, Laura K.

AU - Parker, Kay D.

AU - Monahan, Kristi H.

AU - Foote, Robert L.

AU - Herman, Michael G.

AU - Packer, Douglas L.

PY - 2019/11

Y1 - 2019/11

N2 - Background: Noninvasive cardiac ablation of ventricular tachycardia (VT) using radiotherapy has recently gained interest among electrophysiologists. The effects of left ventricular (LV) ablative radiation treatment on global LV function and volumes are unknown. Objective: The purpose of this study was to investigate the effects of noninvasive ablation on LV function over time. Methods: Twenty domestic swine underwent proton beam treatment of LV sites in a dose-finding design and were followed for up to 40 weeks by cardiac magnetic resonance imaging at 4-week intervals. Doses investigated were either 40 Gy at 1 site (n = 8) or 30 Gy at 2 sites (n = 4) in the low-dose group and 40 Gy at 3 sites (n = 8) in the high-dose group. Results: LV mean dose (13.2 ± 1.8 Gy vs 4.6 ± 1.8 Gy) and the volume receiving at least 20 Gy (V20Gy) (24.7% ± 4.8% vs 6.4% ± 3.0%) differed significantly between groups. Dose-dependent effects on left ventricular ejection fraction (LVEF) and LV end-diastolic volume became manifest about 3 months after treatment. LVEF decline was correlated to mean dose (correlation coefficient ρ = –0.69; P = .008) and V20Gy (ρ = –0.66; P = .01), as was LV dilation (ρ = 0.72; P = .005; and ρ = 0.75, P = .003 respectively). Conclusion: Possible adverse effects on LV function, seen about 3 months after treatment, are dose dependent. Therefore, precise target definition and focused energy delivery are paramount in catheter-free ablation.

AB - Background: Noninvasive cardiac ablation of ventricular tachycardia (VT) using radiotherapy has recently gained interest among electrophysiologists. The effects of left ventricular (LV) ablative radiation treatment on global LV function and volumes are unknown. Objective: The purpose of this study was to investigate the effects of noninvasive ablation on LV function over time. Methods: Twenty domestic swine underwent proton beam treatment of LV sites in a dose-finding design and were followed for up to 40 weeks by cardiac magnetic resonance imaging at 4-week intervals. Doses investigated were either 40 Gy at 1 site (n = 8) or 30 Gy at 2 sites (n = 4) in the low-dose group and 40 Gy at 3 sites (n = 8) in the high-dose group. Results: LV mean dose (13.2 ± 1.8 Gy vs 4.6 ± 1.8 Gy) and the volume receiving at least 20 Gy (V20Gy) (24.7% ± 4.8% vs 6.4% ± 3.0%) differed significantly between groups. Dose-dependent effects on left ventricular ejection fraction (LVEF) and LV end-diastolic volume became manifest about 3 months after treatment. LVEF decline was correlated to mean dose (correlation coefficient ρ = –0.69; P = .008) and V20Gy (ρ = –0.66; P = .01), as was LV dilation (ρ = 0.72; P = .005; and ρ = 0.75, P = .003 respectively). Conclusion: Possible adverse effects on LV function, seen about 3 months after treatment, are dose dependent. Therefore, precise target definition and focused energy delivery are paramount in catheter-free ablation.

KW - Cardiac function

KW - Catheter-free ablation

KW - Proton beam therapy

KW - Radiation therapy

KW - Ventricular tachycardia

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