Left Ventricular Form and Function Revisited: Applied Translational Science to Cardiovascular Ultrasound Imaging

Partho P. Sengupta, Vijay K. Krishnamoorthy, Josef Korinek, Jagat Narula, Mani A. Vannan, Steven J. Lester, Jamil A. Tajik, James B. Seward, Bijoy K. Khandheria, Marek Belohlavek

Research output: Contribution to journalReview article

210 Scopus citations


Doppler tissue imaging (DTI) and DTI-derived strain imaging are robust physiologic tools used for the noninvasive assessment of regional myocardial function. As a result of high temporal and spatial resolution, regional function can be assessed for each phase of the cardiac cycle and within the transmural layers of the myocardial wall. Newer techniques that measure myocardial motion by speckle tracking in gray-scale images have overcome the angle dependence of DTI strain, allowing for measurement of 2-dimensional strain and cardiac rotation. DTI, DTI strain, and speckle tracking may provide unique information that deciphers the deformation sequence of complexly oriented myofibers in the left ventricular wall. The data are, however, limited. This review examines the structure and function of the left ventricle relative to the potential clinical application of DTI and speckle tracking in assessing the global mechanical sequence of the left ventricle in vivo.

Original languageEnglish (US)
Pages (from-to)539-551
Number of pages13
JournalJournal of the American Society of Echocardiography
Issue number5
StatePublished - May 1 2007


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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