Left ventricular assist device bridge therapy for acute myocardial infarction

Soon J. Park, Duc Q. Nguyen, Alan J. Bank, Sofia Ormaza, R. Morton Bolman

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Background. Patients with acute myocardial infarction (AMI) complicated by cardiogenic shock have a high mortality rate. Current treatment modalities remain suboptimal for these patients. Methods. From April 1995 to March 1998, 7 patients were identified as having AMI associated with cardiogenic shock. All received intraaortic balloon pump assistance, in addition to maximal inotropic support. Results. The mean preoperative cardiac index was 2.0 ± 0.3 L/min/m2 and pulmonary capillary wedge pressure was 23 ± 6 mm Hg. Three patients received thrombolytic therapy and 4 patients underwent percutaneous transluminal coronary angioplasty without success. Left ventricular assist devices (LVADs) were implanted as bridge therapy to heart transplantation. One patient died from recurrence of a ventricular septal defect during LVAD support. Six patients were transplanted successfully after mean LVAD support of 59 ± 33 days. Five patients are alive and well at a mean follow-up of 898 ± 447 days. One patient died 3 days after transplantation from acute allograft dysfunction. Conclusions. Timely application of LVADs as bridge therapy to heart transplantation in these critically ill patients can be lifesaving, and should be investigated further.

Original languageEnglish (US)
Pages (from-to)1146-1151
Number of pages6
JournalAnnals of Thoracic Surgery
Volume69
Issue number4
DOIs
StatePublished - Apr 2000

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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    Park, S. J., Nguyen, D. Q., Bank, A. J., Ormaza, S., & Bolman, R. M. (2000). Left ventricular assist device bridge therapy for acute myocardial infarction. Annals of Thoracic Surgery, 69(4), 1146-1151. https://doi.org/10.1016/S0003-4975(99)01575-1