Left Atrial Appendage Occlusion for The Unmet Clinical Needs of Stroke Prevention in Nonvalvular Atrial Fibrillation

David R. Holmes, Mohamad Alkhouli, Vivek Reddy

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Oral anticoagulation is the dominant strategy for stroke prevention in patients with nonvalvular atrial fibrillation. However, lifelong oral anticoagulation is associated with major issues including inappropriate dosing, nonadherence, and adverse effects. Therefore, efforts have been made to develop site-specific therapy aimed to occlude the left atrial appendage, the anatomical site accountable for more than 90% of nonvalvular atrial fibrillation–related ischemic strokes. This review focuses on the growing literature to put into perspective the risk-balance ratio of left atrial appendage occlusion.

Original languageEnglish (US)
Pages (from-to)864-874
Number of pages11
JournalMayo Clinic proceedings
Volume94
Issue number5
DOIs
StatePublished - May 2019

ASJC Scopus subject areas

  • Medicine(all)

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