TY - JOUR
T1 - Left Atrial Appendage Occlusion for The Unmet Clinical Needs of Stroke Prevention in Nonvalvular Atrial Fibrillation
AU - Holmes, David R.
AU - Alkhouli, Mohamad
AU - Reddy, Vivek
N1 - Publisher Copyright:
© 2019 Mayo Foundation for Medical Education and Research
PY - 2019/5
Y1 - 2019/5
N2 - Oral anticoagulation is the dominant strategy for stroke prevention in patients with nonvalvular atrial fibrillation. However, lifelong oral anticoagulation is associated with major issues including inappropriate dosing, nonadherence, and adverse effects. Therefore, efforts have been made to develop site-specific therapy aimed to occlude the left atrial appendage, the anatomical site accountable for more than 90% of nonvalvular atrial fibrillation–related ischemic strokes. This review focuses on the growing literature to put into perspective the risk-balance ratio of left atrial appendage occlusion.
AB - Oral anticoagulation is the dominant strategy for stroke prevention in patients with nonvalvular atrial fibrillation. However, lifelong oral anticoagulation is associated with major issues including inappropriate dosing, nonadherence, and adverse effects. Therefore, efforts have been made to develop site-specific therapy aimed to occlude the left atrial appendage, the anatomical site accountable for more than 90% of nonvalvular atrial fibrillation–related ischemic strokes. This review focuses on the growing literature to put into perspective the risk-balance ratio of left atrial appendage occlusion.
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U2 - 10.1016/j.mayocp.2018.09.025
DO - 10.1016/j.mayocp.2018.09.025
M3 - Review article
C2 - 30962008
AN - SCOPUS:85063911806
SN - 0025-6196
VL - 94
SP - 864
EP - 874
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 5
ER -