TY - JOUR
T1 - Left atrial appendage occlusion
AU - Holmes, David R.
AU - Korsholm, Kasper
AU - Rodés-Cabau, Josep
AU - Saw, Jacqueline
AU - Berti, Sergio
AU - Alkhouli, Mohamad A.
N1 - Publisher Copyright:
© Europa Digital & Publishing 2023. All rights reserved.
PY - 2023/2
Y1 - 2023/2
N2 - Prevention of stroke represents a goal of primary importance in health systems due to its associated morbidity and mortality. As several patient groups with increased stroke rates have been identified, multiple approaches have been developed and implemented: oral anticoagulation (OAC) for patients with atrial fibrillation, surgical and percutaneous revascularisation in patients with carotid disease, device closure for patients with patent foramen ovale, and now, left atrial appendage occlusion (LAAO) for selected patients with non-valvular atrial fibrillation (NVAF). The latter group of patients are the focus of this review which evaluates the pathophysiology, selection of patients, procedural performance, outcomes of treatment both during and post-procedure, adjunctive therapy, complications, and longer-term outcomes.
AB - Prevention of stroke represents a goal of primary importance in health systems due to its associated morbidity and mortality. As several patient groups with increased stroke rates have been identified, multiple approaches have been developed and implemented: oral anticoagulation (OAC) for patients with atrial fibrillation, surgical and percutaneous revascularisation in patients with carotid disease, device closure for patients with patent foramen ovale, and now, left atrial appendage occlusion (LAAO) for selected patients with non-valvular atrial fibrillation (NVAF). The latter group of patients are the focus of this review which evaluates the pathophysiology, selection of patients, procedural performance, outcomes of treatment both during and post-procedure, adjunctive therapy, complications, and longer-term outcomes.
KW - anticoagulation
KW - atrial fibrillation
KW - ischaemic stroke
KW - left atrial appendage occlusion
UR - http://www.scopus.com/inward/record.url?scp=85147789761&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85147789761&partnerID=8YFLogxK
U2 - 10.4244/EIJ-D-22-00627
DO - 10.4244/EIJ-D-22-00627
M3 - Article
C2 - 36760206
AN - SCOPUS:85147789761
SN - 1774-024X
VL - 18
SP - E1038-E1065
JO - EuroIntervention
JF - EuroIntervention
IS - 13
ER -