Left atrial appendage ligation and exclusion technology in the incubator

Faisal F. Syed, Amit Noheria, Christopher V. De Simone, Samuel J Asirvatham

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Stroke is the most feared complication of atrial fibrillation (AF). Targeting the left atrial appendage (LAA) mechanically is attractive as a means to simultaneously reduce stroke risk, the need for anticoagulation, and hemorrhagic complications in patients with non-valvular AF. The results of the PROTECT-AF and PREVAIL randomized clinical trials support this approach as a viable therapeutic alternative to warfarin in selected patients and add to accumulating evidence regarding the importance of the LAA in thromboembolism in AF. A number of devices for percutaneous LAA closure are under investigation or development. In this article, key design features of these ligation and exclusion technologies will be discussed, with a focus on aspects of LAA morphology, relational anatomy, thrombosis, and thromboembolism relevant for successful device development and deployment.

Original languageEnglish (US)
Pages (from-to)61-70
Number of pages10
JournalJournal of Atrial Fibrillation
Issue number2
StatePublished - Aug 1 2015


  • Anatomy
  • Device
  • Exclusion
  • Left Atrial Appendage
  • Ligation
  • Technology
  • Thromboembolism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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