Left Atrial Appendage Closure for Stroke Prevention in Atrial Fibrillation

Erin A. Fender; Jawad G. Kiani; David R. Holmes

doi:10.1007/s11883-016-0616-z

Left Atrial Appendage Closure for Stroke Prevention in Atrial Fibrillation

Erin A. Fender, Jawad G. Kiani, David R. Holmes

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Purpose of Review: Anticoagulant therapy effectively reduces the incidence of stroke in patients with atrial fibrillation (AF) but is underutilized and frequently contraindicated. The left atrial appendage (LAA) is the primary site of thrombus formation in AF patients. Surgical and percutaneous appendage closure has been evaluated as a site-specific therapy to reduce systemic thromboembolism. Recent Findings: We will review LAA closure techniques, examine recent outcome data, and discuss the indications for, and potential complications of, each approach. Summary: Randomized data examining surgical LAA closure and epicardial closure with the LARIAT device are lacking. High quality, randomized data supports the efficacy of the WATCHMAN device for stroke prevention in patients with AF.

Original language	English (US)
Article number	65
Journal	Current atherosclerosis reports
Volume	18
Issue number	11
DOIs	https://doi.org/10.1007/s11883-016-0616-z
State	Published - Nov 1 2016

Keywords

Atrial fibrillation
Lariat
Left atrial appendage closure
Stroke
Watchman

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1007/s11883-016-0616-z

Cite this

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title = "Left Atrial Appendage Closure for Stroke Prevention in Atrial Fibrillation",

abstract = "Purpose of Review: Anticoagulant therapy effectively reduces the incidence of stroke in patients with atrial fibrillation (AF) but is underutilized and frequently contraindicated. The left atrial appendage (LAA) is the primary site of thrombus formation in AF patients. Surgical and percutaneous appendage closure has been evaluated as a site-specific therapy to reduce systemic thromboembolism. Recent Findings: We will review LAA closure techniques, examine recent outcome data, and discuss the indications for, and potential complications of, each approach. Summary: Randomized data examining surgical LAA closure and epicardial closure with the LARIAT device are lacking. High quality, randomized data supports the efficacy of the WATCHMAN device for stroke prevention in patients with AF.",

keywords = "Atrial fibrillation, Lariat, Left atrial appendage closure, Stroke, Watchman",

author = "Fender, {Erin A.} and Kiani, {Jawad G.} and Holmes, {David R.}",

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year = "2016",

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doi = "10.1007/s11883-016-0616-z",

language = "English (US)",

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journal = "Current atherosclerosis reports",

issn = "1523-3804",

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T1 - Left Atrial Appendage Closure for Stroke Prevention in Atrial Fibrillation

AU - Fender, Erin A.

AU - Kiani, Jawad G.

AU - Holmes, David R.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Purpose of Review: Anticoagulant therapy effectively reduces the incidence of stroke in patients with atrial fibrillation (AF) but is underutilized and frequently contraindicated. The left atrial appendage (LAA) is the primary site of thrombus formation in AF patients. Surgical and percutaneous appendage closure has been evaluated as a site-specific therapy to reduce systemic thromboembolism. Recent Findings: We will review LAA closure techniques, examine recent outcome data, and discuss the indications for, and potential complications of, each approach. Summary: Randomized data examining surgical LAA closure and epicardial closure with the LARIAT device are lacking. High quality, randomized data supports the efficacy of the WATCHMAN device for stroke prevention in patients with AF.

AB - Purpose of Review: Anticoagulant therapy effectively reduces the incidence of stroke in patients with atrial fibrillation (AF) but is underutilized and frequently contraindicated. The left atrial appendage (LAA) is the primary site of thrombus formation in AF patients. Surgical and percutaneous appendage closure has been evaluated as a site-specific therapy to reduce systemic thromboembolism. Recent Findings: We will review LAA closure techniques, examine recent outcome data, and discuss the indications for, and potential complications of, each approach. Summary: Randomized data examining surgical LAA closure and epicardial closure with the LARIAT device are lacking. High quality, randomized data supports the efficacy of the WATCHMAN device for stroke prevention in patients with AF.

KW - Atrial fibrillation

KW - Lariat

KW - Left atrial appendage closure

KW - Stroke

KW - Watchman

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DO - 10.1007/s11883-016-0616-z

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JO - Current atherosclerosis reports

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Left Atrial Appendage Closure for Stroke Prevention in Atrial Fibrillation

Abstract

Keywords

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