Left atrial appendage closure for stroke prevention emerging technologies

Faisal F. Syed; Paul A. Friedman

doi:10.1016/j.ccep.2013.12.002

Left atrial appendage closure for stroke prevention emerging technologies

Faisal F. Syed, Paul A. Friedman

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Current anticoagulant therapies aimed at stroke prevention in atrial fibrillation (AF) are increasingly challenged by a complex patient population at significant risk of bleeding. Mounting evidence shows that left atrial appendage (LAA) closure is an effective strategy for reducing stroke risk in patients with nonvalvular AF, without the need for anticoagulation. Several approaches and devices have been developed in recent years, each with their own set of advantages and disadvantages. This article reviews these approaches, identifies pertinent aspects, and outlines necessary or ongoing research in establishing LAA closure as a safe and effective approach to stroke risk reduction.

Original language	English (US)
Pages (from-to)	141-160
Number of pages	20
Journal	Cardiac Electrophysiology Clinics
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/j.ccep.2013.12.002
State	Published - Mar 2014

Keywords

Atrial fibrillation
Cardioembolic risk
Left atrial appendage closure
Stroke

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1016/j.ccep.2013.12.002

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abstract = "Current anticoagulant therapies aimed at stroke prevention in atrial fibrillation (AF) are increasingly challenged by a complex patient population at significant risk of bleeding. Mounting evidence shows that left atrial appendage (LAA) closure is an effective strategy for reducing stroke risk in patients with nonvalvular AF, without the need for anticoagulation. Several approaches and devices have been developed in recent years, each with their own set of advantages and disadvantages. This article reviews these approaches, identifies pertinent aspects, and outlines necessary or ongoing research in establishing LAA closure as a safe and effective approach to stroke risk reduction.",

keywords = "Atrial fibrillation, Cardioembolic risk, Left atrial appendage closure, Stroke",

author = "Syed, {Faisal F.} and Friedman, {Paul A.}",

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AU - Syed, Faisal F.

AU - Friedman, Paul A.

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N2 - Current anticoagulant therapies aimed at stroke prevention in atrial fibrillation (AF) are increasingly challenged by a complex patient population at significant risk of bleeding. Mounting evidence shows that left atrial appendage (LAA) closure is an effective strategy for reducing stroke risk in patients with nonvalvular AF, without the need for anticoagulation. Several approaches and devices have been developed in recent years, each with their own set of advantages and disadvantages. This article reviews these approaches, identifies pertinent aspects, and outlines necessary or ongoing research in establishing LAA closure as a safe and effective approach to stroke risk reduction.

AB - Current anticoagulant therapies aimed at stroke prevention in atrial fibrillation (AF) are increasingly challenged by a complex patient population at significant risk of bleeding. Mounting evidence shows that left atrial appendage (LAA) closure is an effective strategy for reducing stroke risk in patients with nonvalvular AF, without the need for anticoagulation. Several approaches and devices have been developed in recent years, each with their own set of advantages and disadvantages. This article reviews these approaches, identifies pertinent aspects, and outlines necessary or ongoing research in establishing LAA closure as a safe and effective approach to stroke risk reduction.

KW - Atrial fibrillation

KW - Cardioembolic risk

KW - Left atrial appendage closure

KW - Stroke

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Left atrial appendage closure for stroke prevention emerging technologies

Abstract

Keywords

ASJC Scopus subject areas

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