Abstract
Hepatitis C virus (HCV) genotype 4 accounts for 8-13% of all chronic HCV infections worldwide. Patients with HCV genotype 4 have been reported to have poor treatment responses to PEGylated interferon and ribavirin regimens. Recently a single tablet, fixed-dose combination ofsofos- buvir, an RNA-directed RNA polymerase (NS5B) inhibitor, and ledipasvir, a nonstructural protein 5A (NS5A) inhibitor; has been approved for treatment of chronic HCV infection. Two studies using the fixed-dose combination in chronic HCV genotype 4 for 12 weeks reported sustained virologic response rates at 12 weeks (SVR12) of 93-95%. Data also support the use of ledipasvir/sofosbuvir in chronic HCV genotype 4 and HIV co-infection. Administered as a single once-daily oral regimeni, this ribavirin- And interferon-free regimen is well tolerated, with low potential for adverse effects and represents a significant advancement in the treatment of chronic HCV genotype 4 infection.
Original language | English (US) |
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Pages (from-to) | 111-117 |
Number of pages | 7 |
Journal | Drugs of Today |
Volume | 52 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2016 |
Keywords
- Directed RNA polymerase (NS5B) inhibitors
- Fixed-dose combination
- HCV nonstructural protein 5A (NS5A) inhibitors
- Hepatitis C virus
- Ledipasvir/sofosbuvir
- RNA
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)