Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation

Jonathan Miller, Andrew J. Watrous, Melina Tsitsiklis, Sang Ah Lee, Sameer A. Sheth, Catherine A. Schevon, Elliot H. Smith, Michael R. Sperling, Ashwini Sharan, Ali Akbar Asadi-Pooya, Gregory Alan Worrell, Stephen Meisenhelter, Cory S. Inman, Kathryn A. Davis, Bradley Lega, Paul A. Wanda, Sandhitsu R. Das, Joel M. Stein, Richard Gorniak, Joshua Jacobs

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The hippocampus plays a vital role in various aspects of cognition including both memory and spatial navigation. To understand electrophysiologically how the hippocampus supports these processes, we recorded intracranial electroencephalographic activity from 46 neurosurgical patients as they performed a spatial memory task. We measure signals from multiple brain regions, including both left and right hippocampi, and we use spectral analysis to identify oscillatory patterns related to memory encoding and navigation. We show that in the left but not right hippocampus, the amplitude of oscillations in the 1-3-Hz "low theta" band increases when viewing subsequently remembered object-location pairs. In contrast, in the right but not left hippocampus, low-theta activity increases during periods of navigation. The frequencies of these hippocampal signals are slower than task-related signals in the neocortex. These results suggest that the human brain includes multiple lateralized oscillatory networks that support different aspects of cognition.

Original languageEnglish (US)
Article number2423
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

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hippocampus
navigation
Hippocampus
Navigation
Data storage equipment
oscillations
Brain
cognition
Cognition
brain
Spectrum analysis
Neocortex
spectrum analysis
coding
Spatial Navigation
Spatial Memory

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Miller, J., Watrous, A. J., Tsitsiklis, M., Lee, S. A., Sheth, S. A., Schevon, C. A., ... Jacobs, J. (2018). Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation. Nature Communications, 9(1), [2423]. https://doi.org/10.1038/s41467-018-04847-9

Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation. / Miller, Jonathan; Watrous, Andrew J.; Tsitsiklis, Melina; Lee, Sang Ah; Sheth, Sameer A.; Schevon, Catherine A.; Smith, Elliot H.; Sperling, Michael R.; Sharan, Ashwini; Asadi-Pooya, Ali Akbar; Worrell, Gregory Alan; Meisenhelter, Stephen; Inman, Cory S.; Davis, Kathryn A.; Lega, Bradley; Wanda, Paul A.; Das, Sandhitsu R.; Stein, Joel M.; Gorniak, Richard; Jacobs, Joshua.

In: Nature Communications, Vol. 9, No. 1, 2423, 01.12.2018.

Research output: Contribution to journalArticle

Miller, J, Watrous, AJ, Tsitsiklis, M, Lee, SA, Sheth, SA, Schevon, CA, Smith, EH, Sperling, MR, Sharan, A, Asadi-Pooya, AA, Worrell, GA, Meisenhelter, S, Inman, CS, Davis, KA, Lega, B, Wanda, PA, Das, SR, Stein, JM, Gorniak, R & Jacobs, J 2018, 'Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation', Nature Communications, vol. 9, no. 1, 2423. https://doi.org/10.1038/s41467-018-04847-9
Miller, Jonathan ; Watrous, Andrew J. ; Tsitsiklis, Melina ; Lee, Sang Ah ; Sheth, Sameer A. ; Schevon, Catherine A. ; Smith, Elliot H. ; Sperling, Michael R. ; Sharan, Ashwini ; Asadi-Pooya, Ali Akbar ; Worrell, Gregory Alan ; Meisenhelter, Stephen ; Inman, Cory S. ; Davis, Kathryn A. ; Lega, Bradley ; Wanda, Paul A. ; Das, Sandhitsu R. ; Stein, Joel M. ; Gorniak, Richard ; Jacobs, Joshua. / Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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