Late toxicity after postprostatectomy salvage radiation therapy

Jennifer L. Peterson, Steven J. Buskirk, Michael G. Heckman, Julia E. Crook, Stephen J. Ko, Michael J. Wehle, Todd C. Igel, Karin A. Prussak, Thomas M. Pisansky

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Purpose: To evaluate late toxicity in patients who received salvage external beam radiotherapy (EBRT) for a detectable prostate-specific antigen (PSA) level after radical prostatectomy (RP). Methods: A cohort of 308 consecutive patients underwent salvage EBRT from July 1987 through June 2003 for a detectable PSA level after RP. All were treated with high-energy photons (6-20 MV) to a median dose of 64.8 Gy (range: 54.0-72.4 Gy) in 1.8- to 2.0-Gy fractions. Results: Median follow-up from the completion of EBRT was 60 months (range: 1 day-174 months). Late toxicity occurring more than 90 days after EBRT completion was identified in 41 patients (13%). Twelve patients (3.9%) had grade 2 urethral strictures and were treated with urethral dilation, 3 patients had grade 3 cystitis, and 1 had a grade 4 rectal complication. These numbers correspond to an estimated 0.7% (95% confidence interval, 0.0-1.6%) of patients experiencing a grade 3 or 4 complication by 5 years after the start of EBRT. Conclusions: Salvage EBRT for a detectable PSA level after RP is the only curative treatment in this setting. This treatment can be administered in a manner that results in a low likelihood of late complications.

Original languageEnglish (US)
Pages (from-to)203-206
Number of pages4
JournalRadiotherapy and Oncology
Volume93
Issue number2
DOIs
StatePublished - Nov 1 2009

Keywords

  • Adjuvant therapy
  • Prostate-specific antigen
  • Radiotherapy

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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    Peterson, J. L., Buskirk, S. J., Heckman, M. G., Crook, J. E., Ko, S. J., Wehle, M. J., Igel, T. C., Prussak, K. A., & Pisansky, T. M. (2009). Late toxicity after postprostatectomy salvage radiation therapy. Radiotherapy and Oncology, 93(2), 203-206. https://doi.org/10.1016/j.radonc.2009.08.035