TY - JOUR
T1 - Late Midlife Subclinical Infarct Burden and Risk of Dementia
T2 - The Atherosclerosis Risk in Communities Neurocognitive Study
AU - Sullivan, Kevin J.
AU - Griswold, Michael E.
AU - Ghelani, Kunali
AU - Rajesh, Aishwarya
AU - Shrestha, Srishti
AU - Gottesman, Rebecca F.
AU - Knopman, David
AU - Mosley, Thomas H.
AU - Windham, B. Gwen
N1 - Publisher Copyright:
© 2023-IOS Press. All rights reserved.
PY - 2023
Y1 - 2023
N2 - At visit 3 (1993-1995) of the ARIC Study, 1.5T brain MRI was completed in 1,881 stroke-free participants (Mean age=62.9±4.9, 50% Black). Cox regression examined associations between infarct group [infarct-free (referent; n=1,611), smaller only (<3mm; n=50), larger only (≥3mm but <20mm; n=185), both (n=35)] and up to 25-year incident dementia (n=539). Participants with both infarcts were over 2.5 times more likely to develop dementia [HR=2.61; 95% CI=1.44, 4.72]. Smaller only (HR=1.22; 95% CI=0.70, 2.13) and larger only (HR=1.27; 95% CI=0.92, 1.74) groups showed associations with wide confidence intervals, unsupported statistically. A late midlife infarct profile including smaller and larger infarcts may represent particular vulnerability to dementia risk.
AB - At visit 3 (1993-1995) of the ARIC Study, 1.5T brain MRI was completed in 1,881 stroke-free participants (Mean age=62.9±4.9, 50% Black). Cox regression examined associations between infarct group [infarct-free (referent; n=1,611), smaller only (<3mm; n=50), larger only (≥3mm but <20mm; n=185), both (n=35)] and up to 25-year incident dementia (n=539). Participants with both infarcts were over 2.5 times more likely to develop dementia [HR=2.61; 95% CI=1.44, 4.72]. Smaller only (HR=1.22; 95% CI=0.70, 2.13) and larger only (HR=1.27; 95% CI=0.92, 1.74) groups showed associations with wide confidence intervals, unsupported statistically. A late midlife infarct profile including smaller and larger infarcts may represent particular vulnerability to dementia risk.
KW - Cerebrovascular disease
KW - cognition
KW - dementia
KW - epidemiology
KW - infarct
UR - http://www.scopus.com/inward/record.url?scp=85147045940&partnerID=8YFLogxK
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U2 - 10.3233/JAD-220746
DO - 10.3233/JAD-220746
M3 - Article
C2 - 36463445
AN - SCOPUS:85147045940
SN - 1387-2877
VL - 91
SP - 543
EP - 549
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 2
ER -