Late Acute and Chronic Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation

Mukta Arora, Corey S. Cutler, Madan H. Jagasia, Joseph Pidala, Xiaoyu Chai, Paul J. Martin, Mary E.D. Flowers, Yoshihiro Inamoto, George L. Chen, William A. Wood, Nandita Khera, Jeanne Palmer, Hien Duong, Sally Arai, Sebastian Mayer, Iskra Pusic, Stephanie J. Lee

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Several distinct graft-versus-host disease (GVHD)-related syndromes have been defined by the National Institutes of Health Consensus Conference. We enrolled a prospective cohort of 911 hematopoietic cell transplantation (HCT) recipients at 13 centers between March 2011 and May 2014 to evaluate 4 GVHD syndromes: late acute GVHD (aGVHD), chronic GVHD (cGVHD), bronchiolitis obliterans syndrome, and cutaneous sclerosis. The median age at HCT was 53.7 years. The majority of patients received a peripheral blood stem cell transplant (81%) following nonmyeloablative or reduced-intensity conditioning (55%). Pediatric age group and use of bone marrow and umbilical cord blood grafts were underrepresented in our cohort (≤11%). The cumulative incidence of late aGVHD (late onset and recurrent) was 10% at a median of 5.5 months post-HCT, that of cGVHD was 47% at a median of 7.4 months, that of bronchiolitis obliterans was 3% at a median of 12.2 months, and that of cutaneous sclerosis was 8% at a median onset of 14.0 months. Late aGVHD and bronchiolitis obliterans had particularly high nonrelapse mortality of 23% and 32%, respectively, by 2 years after diagnosis. The probability of late aGVHD- and cGVHD-free, relapse-free survival was 38% at 1 year post-HCT and 26% at 2 years post-HCT. This multicenter prospective study confirms the high rate of late aGVHD and cGVHD syndromes and supports the need for continuous close monitoring and development of more effective GVHD treatment strategies to improve HCT success.

Original languageEnglish (US)
Pages (from-to)449-455
Number of pages7
JournalBiology of Blood and Marrow Transplantation
Volume22
Issue number3
DOIs
StatePublished - Mar 1 2016

Keywords

  • Bronchiolitis obliterans syndrome
  • Chronic graft-versus-host disease
  • Cutaneous sclerosis
  • Graft-versus-host disease syndromes
  • Hematopoietic cell transplantation
  • Late acute graft-versus-host disease

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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