LASH: A Review of the Current Literature

William Kingston; Rashmi Halker

doi:10.1007/s11916-017-0636-6

LASH: A Review of the Current Literature

William Kingston, Rashmi Halker

Neurology

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Purpose of Review: The purpose of this review is to evaluate and explain our current understanding of a very rare disorder, long-lasting autonomic symptoms with associated hemicranias (LASH). Recent Findings: At present, there are four known cases in the literature of LASH. Its characteristics and reported response to indomethacin link it most closely to the trigeminal autonomic cephalalgias (TACs). Its pathophysiology and epidemiology remain unclear. Summary: Variance in the pain and autonomic symptom relationship in the existing TAC literature along with the reports of TAC sine headache suggests that LASH may represent a far end of the spectrum of TACs, with most similarities to paroxysmal hemicrania (PH) and hemicrania continua (HC).

Original language	English (US)
Article number	36
Journal	Current pain and headache reports
Volume	21
Issue number	8
DOIs	https://doi.org/10.1007/s11916-017-0636-6
State	Published - Aug 1 2017

Keywords

Indomethacin
Lash
Trigeminal autonomic cephalalgia

ASJC Scopus subject areas

Clinical Neurology
Anesthesiology and Pain Medicine

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abstract = "Purpose of Review: The purpose of this review is to evaluate and explain our current understanding of a very rare disorder, long-lasting autonomic symptoms with associated hemicranias (LASH). Recent Findings: At present, there are four known cases in the literature of LASH. Its characteristics and reported response to indomethacin link it most closely to the trigeminal autonomic cephalalgias (TACs). Its pathophysiology and epidemiology remain unclear. Summary: Variance in the pain and autonomic symptom relationship in the existing TAC literature along with the reports of TAC sine headache suggests that LASH may represent a far end of the spectrum of TACs, with most similarities to paroxysmal hemicrania (PH) and hemicrania continua (HC).",

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AB - Purpose of Review: The purpose of this review is to evaluate and explain our current understanding of a very rare disorder, long-lasting autonomic symptoms with associated hemicranias (LASH). Recent Findings: At present, there are four known cases in the literature of LASH. Its characteristics and reported response to indomethacin link it most closely to the trigeminal autonomic cephalalgias (TACs). Its pathophysiology and epidemiology remain unclear. Summary: Variance in the pain and autonomic symptom relationship in the existing TAC literature along with the reports of TAC sine headache suggests that LASH may represent a far end of the spectrum of TACs, with most similarities to paroxysmal hemicrania (PH) and hemicrania continua (HC).

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LASH: A Review of the Current Literature

Abstract

Keywords

ASJC Scopus subject areas

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