Laser-induced stress transients: aqueous pores of membranes

Thomas J.M.D. Flotte, Shun Lee, Hong Zhang, Daniel J. McAuliffe, Jeremy Taitelbaum, Apostolos G. Doukas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Lasers can be used to enhance the delivery of a number of molecules. The model that best fits our data is for the formation of aqueous pores. These pores are present for up to 80 seconds. Our experiments have shown that laser-induced stress transients can be utilized as a vector for intracellular delivery of molecules that may or may not normally cross the cell membrane. These two conditions have been tested with Photofrin and DNA. This technology may have applications in cell and molecular biology, cancer therapy, gene therapy, and others.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Pages160-166
Number of pages7
Volume2681
DOIs
StatePublished - Jan 1 1996
Externally publishedYes
EventLaser-Tissue Interaction VII - San Jose, CA, USA
Duration: Jan 29 1996Feb 1 1996

Other

OtherLaser-Tissue Interaction VII
CitySan Jose, CA, USA
Period1/29/962/1/96

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Laser-induced stress transients: aqueous pores of membranes'. Together they form a unique fingerprint.

  • Cite this

    Flotte, T. J. M. D., Lee, S., Zhang, H., McAuliffe, D. J., Taitelbaum, J., & Doukas, A. G. (1996). Laser-induced stress transients: aqueous pores of membranes. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2681, pp. 160-166) https://doi.org/10.1117/12.239569