Laser-induced stress transients: aqueous pores of membranes

Thomas J Flotte, Shun Lee, Hong Zhang, Daniel J. McAuliffe, Jeremy Taitelbaum, Apostolos G. Doukas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Lasers can be used to enhance the delivery of a number of molecules. The model that best fits our data is for the formation of aqueous pores. These pores are present for up to 80 seconds. Our experiments have shown that laser-induced stress transients can be utilized as a vector for intracellular delivery of molecules that may or may not normally cross the cell membrane. These two conditions have been tested with Photofrin and DNA. This technology may have applications in cell and molecular biology, cancer therapy, gene therapy, and others.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsSteven L. Jacques
Pages160-166
Number of pages7
Volume2681
StatePublished - 1996
Externally publishedYes
EventLaser-Tissue Interaction VII - San Jose, CA, USA
Duration: Jan 29 1996Feb 1 1996

Other

OtherLaser-Tissue Interaction VII
CitySan Jose, CA, USA
Period1/29/962/1/96

Fingerprint

Cytology
Membranes
Gene therapy
Molecular biology
Molecules
Lasers
Cell membranes
DNA
Experiments

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Flotte, T. J., Lee, S., Zhang, H., McAuliffe, D. J., Taitelbaum, J., & Doukas, A. G. (1996). Laser-induced stress transients: aqueous pores of membranes. In S. L. Jacques (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2681, pp. 160-166)

Laser-induced stress transients : aqueous pores of membranes. / Flotte, Thomas J; Lee, Shun; Zhang, Hong; McAuliffe, Daniel J.; Taitelbaum, Jeremy; Doukas, Apostolos G.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / Steven L. Jacques. Vol. 2681 1996. p. 160-166.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Flotte, TJ, Lee, S, Zhang, H, McAuliffe, DJ, Taitelbaum, J & Doukas, AG 1996, Laser-induced stress transients: aqueous pores of membranes. in SL Jacques (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 2681, pp. 160-166, Laser-Tissue Interaction VII, San Jose, CA, USA, 1/29/96.
Flotte TJ, Lee S, Zhang H, McAuliffe DJ, Taitelbaum J, Doukas AG. Laser-induced stress transients: aqueous pores of membranes. In Jacques SL, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2681. 1996. p. 160-166
Flotte, Thomas J ; Lee, Shun ; Zhang, Hong ; McAuliffe, Daniel J. ; Taitelbaum, Jeremy ; Doukas, Apostolos G. / Laser-induced stress transients : aqueous pores of membranes. Proceedings of SPIE - The International Society for Optical Engineering. editor / Steven L. Jacques. Vol. 2681 1996. pp. 160-166
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