Large-scale screens for cDNAs with in vivo activity

Adrian Ting, Stefan Lichtenthaler, Ramnik Xavier, Soon Young Na, Shahrooz Rabizadeh, Tara Holmes, Brian Seed

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

The pace of biological investigation has been greatly accelerated by technologies that permit comprehensive inventory of gene expression under diverse conditions. We have been developing and using approaches to understand gene function that are based on functional assessments of gene activity, using automated expression cloning followed by gene knockdown using shRNA or by gene knockout. Some recent developments in expression screens and methods to expedite the formation of targeted mutations in mice are discussed. A resource for large scale quantitative profiling of mRNA abundance is also described.

Original languageEnglish (US)
Title of host publicationGenetics of Autoimmunity
Pages219-229
Number of pages11
StatePublished - 2005

Publication series

NameNovartis Foundation Symposium
Volume267
ISSN (Print)1528-2511

ASJC Scopus subject areas

  • Medicine(all)

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