@article{1a3ccf97c9ac40f7a527aec5a0b3f179,
title = "Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders",
abstract = "Clinical and epidemiological studies have shown that circulatory system diseases and nervous system disorders often co-occur in patients. However, genetic susceptibility factors shared between these disease categories remain largely unknown. Here, we characterized pleiotropy across 107 circulatory system and 40 nervous system traits using an ensemble of methods in the eMERGE Network and UK Biobank. Using a formal test of pleiotropy, five genomic loci demonstrated statistically significant evidence of pleiotropy. We observed region-specific patterns of direction of genetic effects for the two disease categories, suggesting potential antagonistic and synergistic pleiotropy. Our findings provide insights into the relationship between circulatory system diseases and nervous system disorders which can provide context for future prevention and treatment strategies.",
author = "Xinyuan Zhang and Lucas, {Anastasia M.} and Yogasudha Veturi and Drivas, {Theodore G.} and Bone, {William P.} and Anurag Verma and Chung, {Wendy K.} and David Crosslin and Denny, {Joshua C.} and Scott Hebbring and Jarvik, {Gail P.} and Iftikhar Kullo and Larson, {Eric B.} and Rasmussen-Torvik, {Laura J.} and Schaid, {Daniel J.} and Smoller, {Jordan W.} and Stanaway, {Ian B.} and Wei, {Wei Qi} and Chunhua Weng and Ritchie, {Marylyn D.}",
note = "Funding Information: We would like to thank Daniel J. Rader, Yong Chen, Dana C. Crawford, and Li-San Wang for helpful discussion on this project. We would like to thank Rachal Kember and Scott M. Damrauer for providing the manually reviewed ICD-CM conversion map. This work was in part supported by P50GM115318-04S1. eMERGE Network (Phase III). This phase of the eMERGE Network was initiated and funded by the NHGRI through the following grants: U01HG8657 (Group Health Cooperative/University of Washington); U01HG8685 (Brigham and Women{\textquoteright}s Hospital); U01HG8672 (Vanderbilt University Medical Center); U01HG8666 (Cincinnati Children{\textquoteright}s Hospital Medical Center); U01HG6379 (Mayo Clinic); U01HG8679 (Geisinger Clinic); U01HG8680 (Columbia University Health Sciences); U01HG8684 (Children{\textquoteright}s Hospital of Philadelphia); U01HG8673 (Northwestern University); U01HG8701 (Vanderbilt University Medical Center serving as the Coordinating Center); U01HG8676 (Partners Healthcare/Broad Institute); and U01HG8664 (Baylor College of Medicine). UK Biobank. All data for this cohort pertained to project 32133 – “Integration of multi-organ imaging phenotypes, clinical phenotypes, and genomic data”. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1038/s41467-022-30678-w",
language = "English (US)",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}