Large common fragile site genes and cancer

David I. Smith; Sarah McAvoy; Yu Zhu; Damon S. Perez

doi:10.1016/j.semcancer.2006.10.003

Large common fragile site genes and cancer

David I. Smith, Sarah McAvoy, Yu Zhu, Damon S. Perez

Laboratory Medicine and Pathology

Research output: Contribution to journal › Review article › peer-review

83 Scopus citations

Abstract

The common fragile sites are large regions of genomic instability that are found in all individuals and are hot spots for chromosomal rearrangements and deletions. A number of the common fragile sites have been found to span genes that are encoded by very large genomic regions. Two of these genes, FHIT and WWOX, have already been demonstrated to function as tumor suppressors. In this review we will discuss the large common fragile site genes that have been identified to date, and the role that these genes appear to play both in cellular responses to stress and in the development of cancer.

Original language	English (US)
Pages (from-to)	31-41
Number of pages	11
Journal	Seminars in Cancer Biology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/j.semcancer.2006.10.003
State	Published - Feb 2007

Keywords

Common fragile site
Large genes

ASJC Scopus subject areas

Cancer Research

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10.1016/j.semcancer.2006.10.003

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title = "Large common fragile site genes and cancer",

abstract = "The common fragile sites are large regions of genomic instability that are found in all individuals and are hot spots for chromosomal rearrangements and deletions. A number of the common fragile sites have been found to span genes that are encoded by very large genomic regions. Two of these genes, FHIT and WWOX, have already been demonstrated to function as tumor suppressors. In this review we will discuss the large common fragile site genes that have been identified to date, and the role that these genes appear to play both in cellular responses to stress and in the development of cancer.",

keywords = "Common fragile site, Large genes",

author = "Smith, {David I.} and Sarah McAvoy and Yu Zhu and Perez, {Damon S.}",

note = "Funding Information: The work that we have done on the characterization of large CFS genes was supported by Department of Defense grant no. DAMD 17-00-1-0296, a grant from the Minnesota Ovarian Cancer Alliance, and a grant from the Eagle's Foundation.",

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AU - McAvoy, Sarah

AU - Zhu, Yu

AU - Perez, Damon S.

N1 - Funding Information: The work that we have done on the characterization of large CFS genes was supported by Department of Defense grant no. DAMD 17-00-1-0296, a grant from the Minnesota Ovarian Cancer Alliance, and a grant from the Eagle's Foundation.

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N2 - The common fragile sites are large regions of genomic instability that are found in all individuals and are hot spots for chromosomal rearrangements and deletions. A number of the common fragile sites have been found to span genes that are encoded by very large genomic regions. Two of these genes, FHIT and WWOX, have already been demonstrated to function as tumor suppressors. In this review we will discuss the large common fragile site genes that have been identified to date, and the role that these genes appear to play both in cellular responses to stress and in the development of cancer.

AB - The common fragile sites are large regions of genomic instability that are found in all individuals and are hot spots for chromosomal rearrangements and deletions. A number of the common fragile sites have been found to span genes that are encoded by very large genomic regions. Two of these genes, FHIT and WWOX, have already been demonstrated to function as tumor suppressors. In this review we will discuss the large common fragile site genes that have been identified to date, and the role that these genes appear to play both in cellular responses to stress and in the development of cancer.

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Large common fragile site genes and cancer

Abstract

Keywords

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