Large common fragile site genes and cancer

David I. Smith; Sarah McAvoy; Yu Zhu; Damon S. Perez

doi:10.1016/j.semcancer.2006.10.003

Large common fragile site genes and cancer

David I. Smith, Sarah McAvoy, Yu Zhu, Damon S. Perez

Laboratory Medicine and Pathology

Research output: Contribution to journal › Review article

82 Scopus citations

Abstract

The common fragile sites are large regions of genomic instability that are found in all individuals and are hot spots for chromosomal rearrangements and deletions. A number of the common fragile sites have been found to span genes that are encoded by very large genomic regions. Two of these genes, FHIT and WWOX, have already been demonstrated to function as tumor suppressors. In this review we will discuss the large common fragile site genes that have been identified to date, and the role that these genes appear to play both in cellular responses to stress and in the development of cancer.

Original language	English (US)
Pages (from-to)	31-41
Number of pages	11
Journal	Seminars in Cancer Biology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/j.semcancer.2006.10.003
State	Published - Feb 1 2007

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Keywords

Common fragile site
Large genes

ASJC Scopus subject areas

Cancer Research

Cite this

Smith, D. I., McAvoy, S., Zhu, Y., & Perez, D. S. (2007). Large common fragile site genes and cancer. Seminars in Cancer Biology, 17(1), 31-41. https://doi.org/10.1016/j.semcancer.2006.10.003

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Access to Document

10.1016/j.semcancer.2006.10.003