Laparoscopic versus open posterior adrenalectomy: Comparison of acute- phase response and wound healing in the cushingoid porcine model

Christine F. Kollmorgen, Geoffrey B. Thompson, Clive S. Grant, Jon A. Van Heerden, John Byrne, Edward T. Davies, John H. Donohue, Duane M. Ilstrup, William Francis Young

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

This prospective randomized study examined the acute-phase response and wound healing, comparing laparoscopic (LA) and open posterior (PA) adrenalectomy in a cushingoid porcine model. Repository corticotropin gel was given to 40 pigs for 21 days. Biochemical and tissue parameters of Cushing syndrome were confirmed. The pigs were randomized to undergo LA or PA. In addition to operating time and morbidity, the acute-phase response was compared by measuring the postoperative white blood cell count, fasting glucose, C-reactive protein, and nitrogen balance. Wound healing was assessed by (1) scored (1-4) gross appearance at 48 hours and 1 and 2 weeks; (2) histologic examination; and (3) tensile strength. There was no difference in operating time (mean ± SD) (36 ± 9 minutes open vs. 37 ± 7 minutes laparoscopic), perioperative mortality, degree of leukocytosis, fasting glucose, or C-reactive protein (p > 0.05). Nitrogen balance, wound scores, and tensile strength at 24 and 1 week were more favorable in the LA group than in the PA group (p < 0.05). In the cushingoid porcine model, laparoscopic adrenalectomy was less catabolic and was associated with fewer wound complications than the open posterior adrenalectomy. These findings provide support for continued pursuit of laparoscopic methods for adrenalectomy in the clinical setting.

Original languageEnglish (US)
Pages (from-to)613-620
Number of pages8
JournalWorld Journal of Surgery
Volume22
Issue number6
DOIs
StatePublished - Jun 1998

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Acute-Phase Reaction
Adrenalectomy
Wound Healing
Swine
Tensile Strength
C-Reactive Protein
Fasting
Nitrogen
Glucose
Cushing Syndrome
Leukocytosis
Wounds and Injuries
Leukocyte Count
Adrenocorticotropic Hormone
Gels
Prospective Studies
Morbidity
Mortality

ASJC Scopus subject areas

  • Surgery

Cite this

Laparoscopic versus open posterior adrenalectomy : Comparison of acute- phase response and wound healing in the cushingoid porcine model. / Kollmorgen, Christine F.; Thompson, Geoffrey B.; Grant, Clive S.; Van Heerden, Jon A.; Byrne, John; Davies, Edward T.; Donohue, John H.; Ilstrup, Duane M.; Young, William Francis.

In: World Journal of Surgery, Vol. 22, No. 6, 06.1998, p. 613-620.

Research output: Contribution to journalArticle

Kollmorgen, CF, Thompson, GB, Grant, CS, Van Heerden, JA, Byrne, J, Davies, ET, Donohue, JH, Ilstrup, DM & Young, WF 1998, 'Laparoscopic versus open posterior adrenalectomy: Comparison of acute- phase response and wound healing in the cushingoid porcine model', World Journal of Surgery, vol. 22, no. 6, pp. 613-620. https://doi.org/10.1007/s002689900443
Kollmorgen, Christine F. ; Thompson, Geoffrey B. ; Grant, Clive S. ; Van Heerden, Jon A. ; Byrne, John ; Davies, Edward T. ; Donohue, John H. ; Ilstrup, Duane M. ; Young, William Francis. / Laparoscopic versus open posterior adrenalectomy : Comparison of acute- phase response and wound healing in the cushingoid porcine model. In: World Journal of Surgery. 1998 ; Vol. 22, No. 6. pp. 613-620.
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