Laparoscopic versus open liver resection for hepatocellular carcinoma at a North-American Centre: A 2-to-1 matched pair analysis

Jonghun J. Lee, John B. Conneely, Rory L. Smoot, Steven Gallinger, Paul D. Greig, Carol Anne Moulton, Alice Wei, Ian McGilvray, Sean P. Cleary

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Introduction Oncological implications of laparoscopic resection in primary hepatic malignancy are not well defined. Laparoscopic liver resection (LLR) for hepatocellular carcinoma (HCC) in comparison to an open liver resection (OLR) in peri-operative and long-term oncological outcomes are described from a single North American institution. Methods From 2006 to 2013, all forty-three LLR patients for HCC were evaluated. Each patient was matched to two OLR patients for age at operation, maximal tumour size and tumour number. Results When compared with OLR, LLR had a lower severity of complication (0% versus 27%, P = 0.050) and lower 30-day readmission rate (2.3% versus 18.6%, P = 0.010). The length of stay (LOS) was shorter in LLR patients (5 versus 7 days, P < 0.001) and the estimated blood loss was also lower in LLR (300 versus 700 ml, P = 0.004). Admission to intensive care unit (ICU), emergency room (ER) visits and complication rates were similar. Overall, recurrence-free and intra-hepatic recurrence-free survival were comparable between LLR and OLR. Discussion LLR confers the widely-accepted benefits of laparoscopic surgery, namely severity of complication, 30-day readmission rate, LOS and blood loss. Further studies are required to examine intra- and extra-hepatic recurrence after LLR. LLR for HCC should be considered for appropriately selected patients in centres with requisite volume and expertise.

Original languageEnglish (US)
Pages (from-to)304-310
Number of pages7
JournalHPB
Volume17
Issue number4
DOIs
StatePublished - Apr 1 2015
Externally publishedYes

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Matched-Pair Analysis
varespladib methyl
Hepatocellular Carcinoma
Liver
Recurrence
Length of Stay
Neoplasms

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Lee, J. J., Conneely, J. B., Smoot, R. L., Gallinger, S., Greig, P. D., Moulton, C. A., ... Cleary, S. P. (2015). Laparoscopic versus open liver resection for hepatocellular carcinoma at a North-American Centre: A 2-to-1 matched pair analysis. HPB, 17(4), 304-310. https://doi.org/10.1111/hpb.12342

Laparoscopic versus open liver resection for hepatocellular carcinoma at a North-American Centre : A 2-to-1 matched pair analysis. / Lee, Jonghun J.; Conneely, John B.; Smoot, Rory L.; Gallinger, Steven; Greig, Paul D.; Moulton, Carol Anne; Wei, Alice; McGilvray, Ian; Cleary, Sean P.

In: HPB, Vol. 17, No. 4, 01.04.2015, p. 304-310.

Research output: Contribution to journalArticle

Lee, JJ, Conneely, JB, Smoot, RL, Gallinger, S, Greig, PD, Moulton, CA, Wei, A, McGilvray, I & Cleary, SP 2015, 'Laparoscopic versus open liver resection for hepatocellular carcinoma at a North-American Centre: A 2-to-1 matched pair analysis', HPB, vol. 17, no. 4, pp. 304-310. https://doi.org/10.1111/hpb.12342
Lee, Jonghun J. ; Conneely, John B. ; Smoot, Rory L. ; Gallinger, Steven ; Greig, Paul D. ; Moulton, Carol Anne ; Wei, Alice ; McGilvray, Ian ; Cleary, Sean P. / Laparoscopic versus open liver resection for hepatocellular carcinoma at a North-American Centre : A 2-to-1 matched pair analysis. In: HPB. 2015 ; Vol. 17, No. 4. pp. 304-310.
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N2 - Introduction Oncological implications of laparoscopic resection in primary hepatic malignancy are not well defined. Laparoscopic liver resection (LLR) for hepatocellular carcinoma (HCC) in comparison to an open liver resection (OLR) in peri-operative and long-term oncological outcomes are described from a single North American institution. Methods From 2006 to 2013, all forty-three LLR patients for HCC were evaluated. Each patient was matched to two OLR patients for age at operation, maximal tumour size and tumour number. Results When compared with OLR, LLR had a lower severity of complication (0% versus 27%, P = 0.050) and lower 30-day readmission rate (2.3% versus 18.6%, P = 0.010). The length of stay (LOS) was shorter in LLR patients (5 versus 7 days, P < 0.001) and the estimated blood loss was also lower in LLR (300 versus 700 ml, P = 0.004). Admission to intensive care unit (ICU), emergency room (ER) visits and complication rates were similar. Overall, recurrence-free and intra-hepatic recurrence-free survival were comparable between LLR and OLR. Discussion LLR confers the widely-accepted benefits of laparoscopic surgery, namely severity of complication, 30-day readmission rate, LOS and blood loss. Further studies are required to examine intra- and extra-hepatic recurrence after LLR. LLR for HCC should be considered for appropriately selected patients in centres with requisite volume and expertise.

AB - Introduction Oncological implications of laparoscopic resection in primary hepatic malignancy are not well defined. Laparoscopic liver resection (LLR) for hepatocellular carcinoma (HCC) in comparison to an open liver resection (OLR) in peri-operative and long-term oncological outcomes are described from a single North American institution. Methods From 2006 to 2013, all forty-three LLR patients for HCC were evaluated. Each patient was matched to two OLR patients for age at operation, maximal tumour size and tumour number. Results When compared with OLR, LLR had a lower severity of complication (0% versus 27%, P = 0.050) and lower 30-day readmission rate (2.3% versus 18.6%, P = 0.010). The length of stay (LOS) was shorter in LLR patients (5 versus 7 days, P < 0.001) and the estimated blood loss was also lower in LLR (300 versus 700 ml, P = 0.004). Admission to intensive care unit (ICU), emergency room (ER) visits and complication rates were similar. Overall, recurrence-free and intra-hepatic recurrence-free survival were comparable between LLR and OLR. Discussion LLR confers the widely-accepted benefits of laparoscopic surgery, namely severity of complication, 30-day readmission rate, LOS and blood loss. Further studies are required to examine intra- and extra-hepatic recurrence after LLR. LLR for HCC should be considered for appropriately selected patients in centres with requisite volume and expertise.

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