Laparoscopic adrenalectomy for adrenocorticotropin-dependent Cushing's syndrome

Adrian Vella, Geoffrey B. Thompson, Clive S. Grant, Jon A. Van Heerden, David R. Farley, William Francis Young

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Bilateral adrenalectomy is indicated for the treatment of ACTH-dependent Cushing's syndrome when the tumorous source of ACTH hypersecretion cannot be identified or removed. Potential advantages of laparoscopic over open adrenalectomy include shorter hospitalization, decreased requirement for postoperative analgesia, and decreased postoperative morbidity due to incisional complications. Bilateral laparoscopic adrenalectomy performed for the treatment of ACTH-dependent Cushing's syndrome was attempted in 19 patients at our institution between 1995 and 1998. Conversion to an open procedure was required in three patients. All patients who underwent bilateral laparoscopic adrenalectomy were subsequently followed to assess the outcome of this intervention. Twelve patients with pituitary-dependent Cushing's syndrome and four with ectopic ACTH syndrome underwent successful bilateral laparoscopic adrenalectomy. All patients experienced resolution of the signs and symptoms (e.g. proximal myopathy, hirsutism, and emotional lability) of Cushing's syndrome as well as weight loss, improved glucose tolerance, and improved control of blood pressure. No residual cortisol secretion was detected in the patients. Bilateral laparoscopic adrenalectomy is a safe and effective treatment for Cushing's syndrome when the ACTH-secreting neoplasm cannot be removed.

Original languageEnglish (US)
Pages (from-to)1596-1599
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume86
Issue number4
DOIs
StatePublished - 2001

Fingerprint

Cushing Syndrome
Adrenalectomy
Adrenocorticotropic Hormone
Ectopic ACTH Syndrome
Conversion to Open Surgery
Blood pressure
Pituitary ACTH Hypersecretion
Hirsutism
Muscular Diseases
Hydrocortisone
Analgesia
Signs and Symptoms
Weight Loss
Hospitalization
Therapeutics
Glucose
Blood Pressure
Morbidity
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Laparoscopic adrenalectomy for adrenocorticotropin-dependent Cushing's syndrome. / Vella, Adrian; Thompson, Geoffrey B.; Grant, Clive S.; Van Heerden, Jon A.; Farley, David R.; Young, William Francis.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 86, No. 4, 2001, p. 1596-1599.

Research output: Contribution to journalArticle

Vella, Adrian ; Thompson, Geoffrey B. ; Grant, Clive S. ; Van Heerden, Jon A. ; Farley, David R. ; Young, William Francis. / Laparoscopic adrenalectomy for adrenocorticotropin-dependent Cushing's syndrome. In: Journal of Clinical Endocrinology and Metabolism. 2001 ; Vol. 86, No. 4. pp. 1596-1599.
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