Lanthanide nano-drums: A new class of molecular nanoparticles for potential biomedical applications

Richard A. Jones; Annie J. Gnanam; Jonathan F. Arambula; Jessica N. Jones; Jagannath Swaminathan; Xiaoping Yang; Desmond Schipper; Justin W. Hall; Lauren J. Depue; Yakhya Dieye; Jamuna Vadivelu; Don J. Chandler; Edward M. Marcotte; Jonathan L. Sessler; Lauren I.R. Ehrlich; Katherine A. Brown

doi:10.1039/c4fd00117f

Lanthanide nano-drums: A new class of molecular nanoparticles for potential biomedical applications

Richard A. Jones, Annie J. Gnanam, Jonathan F. Arambula, Jessica N. Jones, Jagannath Swaminathan, Xiaoping Yang, Desmond Schipper, Justin W. Hall, Lauren J. Depue, Yakhya Dieye, Jamuna Vadivelu, Don J. Chandler, Edward M. Marcotte, Jonathan L. Sessler, Lauren I.R. Ehrlich, Katherine A. Brown

Immunology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We are developing a new class of lanthanide-based self-assembling molecular nanoparticles as potential reporter molecules for imaging, and as multi-functional nanoprobes or nanosensors in diagnostic systems. These lanthanide "nano-drums" are homogeneous 4d-4f clusters approximately 25 to 30 Å in diameter that can emit from the visible to near-infrared (NIR) wavelengths. Here, we present syntheses, crystal structures, photophysical properties, and comparative cytotoxicity data for six nano-drums containing either Eu, Tb, Lu, Er, Yb or Ho. Imaging capabilities of these nano-drums are demonstrated using epifluorescence, total internal reflection fluorescence (TIRF), and two-photon microscopy. We discuss how these molecular nanoparticles can to be adapted for a range of assays, particularly by taking advantage of functionalization strategies with chemical moieties to enable conjugation to protein or nucleic acids.

Original language	English (US)
Pages (from-to)	241-255
Number of pages	15
Journal	Faraday Discussions
Volume	175
DOIs	https://doi.org/10.1039/c4fd00117f
State	Published - Dec 8 2014

ASJC Scopus subject areas

Physical and Theoretical Chemistry

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10.1039/c4fd00117f

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Jones, R. A., Gnanam, A. J., Arambula, J. F., Jones, J. N., Swaminathan, J., Yang, X., Schipper, D., Hall, J. W., Depue, L. J., Dieye, Y., Vadivelu, J., Chandler, D. J., Marcotte, E. M., Sessler, J. L., Ehrlich, L. I. R., & Brown, K. A. (2014). Lanthanide nano-drums: A new class of molecular nanoparticles for potential biomedical applications. Faraday Discussions, 175, 241-255. https://doi.org/10.1039/c4fd00117f

Jones, RA, Gnanam, AJ, Arambula, JF, Jones, JN, Swaminathan, J, Yang, X, Schipper, D, Hall, JW, Depue, LJ, Dieye, Y, Vadivelu, J, Chandler, DJ, Marcotte, EM, Sessler, JL, Ehrlich, LIR & Brown, KA 2014, 'Lanthanide nano-drums: A new class of molecular nanoparticles for potential biomedical applications', Faraday Discussions, vol. 175, pp. 241-255. https://doi.org/10.1039/c4fd00117f

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abstract = "We are developing a new class of lanthanide-based self-assembling molecular nanoparticles as potential reporter molecules for imaging, and as multi-functional nanoprobes or nanosensors in diagnostic systems. These lanthanide {"}nano-drums{"} are homogeneous 4d-4f clusters approximately 25 to 30 {\AA} in diameter that can emit from the visible to near-infrared (NIR) wavelengths. Here, we present syntheses, crystal structures, photophysical properties, and comparative cytotoxicity data for six nano-drums containing either Eu, Tb, Lu, Er, Yb or Ho. Imaging capabilities of these nano-drums are demonstrated using epifluorescence, total internal reflection fluorescence (TIRF), and two-photon microscopy. We discuss how these molecular nanoparticles can to be adapted for a range of assays, particularly by taking advantage of functionalization strategies with chemical moieties to enable conjugation to protein or nucleic acids.",

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AU - Swaminathan, Jagannath

AU - Yang, Xiaoping

AU - Schipper, Desmond

AU - Hall, Justin W.

AU - Depue, Lauren J.

AU - Dieye, Yakhya

AU - Vadivelu, Jamuna

AU - Chandler, Don J.

AU - Marcotte, Edward M.

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AU - Brown, Katherine A.

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Lanthanide nano-drums: A new class of molecular nanoparticles for potential biomedical applications

Abstract

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