LANT-6, xenopsin and neuromedin N stimulate cyclic GMP at neurotensin receptors

Judith A. Gilbert; Elliott Richelson

doi:10.1016/0014-2999(86)90452-8

LANT-6, xenopsin and neuromedin N stimulate cyclic GMP at neurotensin receptors

Judith A. Gilbert, Elliott Richelson

Neuroscience

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The naturally occurring analogs of neurotensin-(8-13), xenopsin, [Lys⁸, Asn⁹]neurotensin-(8-13) (LANT-6) and neuromedin N stimulated the production of intracellular cyclic GMP in murine neuroblastoma clone N1E-115, an adrenergic neuronal cell type. The order of potency was neurotensin-(8-13)>neurotensin>xenopsin>neuromedin N>LANT-6. Furthermore, xenopsin, LANT-6 and neuromedin N each inhibited the specific binding of [³H]neurotensin to intact N1E-115 cells in a dose-related fashion. The order of affinity of the peptides for the neurotensin receptor was neurotensin-(8-13)>xenopsin>neurotensin N>LANT-6.

Original language	English (US)
Pages (from-to)	379-383
Number of pages	5
Journal	European Journal of Pharmacology
Volume	129
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(86)90452-8
State	Published - Oct 7 1986

Keywords

Asn]neurotensin-(8-13)
Clone N1E-115
Neuromedin N
Neurotensin-(8-13)
Xenopsin
[Lys
cyclic GMP

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(86)90452-8

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title = "LANT-6, xenopsin and neuromedin N stimulate cyclic GMP at neurotensin receptors",

abstract = "The naturally occurring analogs of neurotensin-(8-13), xenopsin, [Lys8, Asn9]neurotensin-(8-13) (LANT-6) and neuromedin N stimulated the production of intracellular cyclic GMP in murine neuroblastoma clone N1E-115, an adrenergic neuronal cell type. The order of potency was neurotensin-(8-13)>neurotensin>xenopsin>neuromedin N>LANT-6. Furthermore, xenopsin, LANT-6 and neuromedin N each inhibited the specific binding of [3H]neurotensin to intact N1E-115 cells in a dose-related fashion. The order of affinity of the peptides for the neurotensin receptor was neurotensin-(8-13)>xenopsin>neurotensin N>LANT-6.",

keywords = "Asn]neurotensin-(8-13), Clone N1E-115, Neuromedin N, Neurotensin-(8-13), Xenopsin, [Lys, cyclic GMP",

author = "Gilbert, {Judith A.} and Elliott Richelson",

year = "1986",

month = oct,

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doi = "10.1016/0014-2999(86)90452-8",

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pages = "379--383",

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T1 - LANT-6, xenopsin and neuromedin N stimulate cyclic GMP at neurotensin receptors

AU - Gilbert, Judith A.

AU - Richelson, Elliott

PY - 1986/10/7

Y1 - 1986/10/7

N2 - The naturally occurring analogs of neurotensin-(8-13), xenopsin, [Lys8, Asn9]neurotensin-(8-13) (LANT-6) and neuromedin N stimulated the production of intracellular cyclic GMP in murine neuroblastoma clone N1E-115, an adrenergic neuronal cell type. The order of potency was neurotensin-(8-13)>neurotensin>xenopsin>neuromedin N>LANT-6. Furthermore, xenopsin, LANT-6 and neuromedin N each inhibited the specific binding of [3H]neurotensin to intact N1E-115 cells in a dose-related fashion. The order of affinity of the peptides for the neurotensin receptor was neurotensin-(8-13)>xenopsin>neurotensin N>LANT-6.

AB - The naturally occurring analogs of neurotensin-(8-13), xenopsin, [Lys8, Asn9]neurotensin-(8-13) (LANT-6) and neuromedin N stimulated the production of intracellular cyclic GMP in murine neuroblastoma clone N1E-115, an adrenergic neuronal cell type. The order of potency was neurotensin-(8-13)>neurotensin>xenopsin>neuromedin N>LANT-6. Furthermore, xenopsin, LANT-6 and neuromedin N each inhibited the specific binding of [3H]neurotensin to intact N1E-115 cells in a dose-related fashion. The order of affinity of the peptides for the neurotensin receptor was neurotensin-(8-13)>xenopsin>neurotensin N>LANT-6.

KW - Asn]neurotensin-(8-13)

KW - Clone N1E-115

KW - Neuromedin N

KW - Neurotensin-(8-13)

KW - Xenopsin

KW - [Lys

KW - cyclic GMP

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IS - 3

ER -

LANT-6, xenopsin and neuromedin N stimulate cyclic GMP at neurotensin receptors

Abstract

Keywords

ASJC Scopus subject areas

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