LANT-6, xenopsin and neuromedin N stimulate cyclic GMP at neurotensin receptors

Judith A. Gilbert, Elliott Richelson

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The naturally occurring analogs of neurotensin-(8-13), xenopsin, [Lys8, Asn9]neurotensin-(8-13) (LANT-6) and neuromedin N stimulated the production of intracellular cyclic GMP in murine neuroblastoma clone N1E-115, an adrenergic neuronal cell type. The order of potency was neurotensin-(8-13)>neurotensin>xenopsin>neuromedin N>LANT-6. Furthermore, xenopsin, LANT-6 and neuromedin N each inhibited the specific binding of [3H]neurotensin to intact N1E-115 cells in a dose-related fashion. The order of affinity of the peptides for the neurotensin receptor was neurotensin-(8-13)>xenopsin>neurotensin N>LANT-6.

Original languageEnglish (US)
Pages (from-to)379-383
Number of pages5
JournalEuropean Journal of Pharmacology
Volume129
Issue number3
DOIs
StatePublished - Oct 7 1986

Keywords

  • Asn]neurotensin-(8-13)
  • Clone N1E-115
  • cyclic GMP
  • Neuromedin N
  • Neurotensin-(8-13)
  • Xenopsin
  • [Lys

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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