Langerhans Cell Histiocytosis and Other Histiocytic Diseases of the Lung

Erin DeMartino, Ronald S. Go, Robert Vassallo

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Several histiocytic disorders may affect the thoracic cavity. Pulmonary Langerhans cell histiocytosis (LCH) is the histiocytic disorder that most frequently manifests with thoracic involvement in adults and is associated with cigarette smoking. The histiocytic disorders follow variable clinical courses ranging from benign disease to life-threatening aggressive disorders. Although the pathogenesis is not fully understood, it is now apparent that some of these disorders are associated with activating mutations in cell proliferative/regulatory pathways. Management of these rare disorders must be individualized. Pharmacologic treatment may include the use of chemotherapeutic agents. Smoking cessation is imperative in the management of pulmonary LCH.

Original languageEnglish (US)
Pages (from-to)421-430
Number of pages10
JournalClinics in Chest Medicine
Volume37
Issue number3
DOIs
StatePublished - Sep 1 2016

Keywords

  • BRAF
  • Cigarette smoking
  • Histiocyte
  • Interstitial
  • Langerhans cell
  • Lung
  • Macrophage

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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