Langerhans' cell granulomatosis (histiocytosis X) associated with malignant lymphomas

B. F. Burns, T. V. Colby, R. F. Dorfman

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


We present six patients in whom Langerhans' cell granulomatosis (histiocytosis X) was found in lymph nodes also harboring malignant lymphomas: Hodgkin's disease in five and non-Hodgkin's lymphoma in one. This brings to 12 the total number of such reported cases. Whether this represents a chance association of the two processes or a peculiar reaction of Langerhans' cells to the lymphoma is unknown. The focal intimate intermingling of the two processes and the inability to identify LCG as an incidential finding in other cancers suggests that this phenomenon may represent a peculiar reaction to the lymphoma.

Original languageEnglish (US)
Pages (from-to)529-533
Number of pages5
JournalAmerican Journal of Surgical Pathology
Issue number6
StatePublished - 1983

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine


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