Landscaping the effect of CT reconstruction parameters: Robust Interstitial Pulmonary Fibrosis quantitation

S. Raghunath, S. Rajagopalan, R. A. Karwoski, M. R. Bruesewitz, C. H. McCollough, B. J. Bartholmai, R. A. Robb

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Inter- and intra-rater agreement in assessing Interstitial Pulmonary Fibrosis (IPF) on CT scans is poor. Lack of approaches to understand the nuances of CT reconstruction parameters and their effect on patient scans hampers objective IPF quantification. In this paper, we propose an image analytic methodology to characterize the relationship between CT reconstruction parameters and IPF manifestation in scans. The raw data acquired from a patient was reconstructed with a combination of image thickness, interval and reconstruction kernels to derive 104 datasets. Quantitative and qualitative analyses were performed on the regional statistics computed in the neighborhood of each parenchymal voxel and for expert-chosen regions of interest (ROIs). The proposed approach could facilitate the selection of optimal CT reconstruction parameters to more robustly quantify IPF.

Original languageEnglish (US)
Title of host publicationISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro
Pages374-377
Number of pages4
DOIs
StatePublished - Aug 22 2013
Event2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013 - San Francisco, CA, United States
Duration: Apr 7 2013Apr 11 2013

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013
CountryUnited States
CitySan Francisco, CA
Period4/7/134/11/13

Keywords

  • Diffuse Parenchymal Lung Disease (DPLD)
  • Interstitial Pulmonary Fibrosis (IPF)
  • classification
  • reconstruction kernel
  • slice thickness

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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    Raghunath, S., Rajagopalan, S., Karwoski, R. A., Bruesewitz, M. R., McCollough, C. H., Bartholmai, B. J., & Robb, R. A. (2013). Landscaping the effect of CT reconstruction parameters: Robust Interstitial Pulmonary Fibrosis quantitation. In ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro (pp. 374-377). [6556490] (Proceedings - International Symposium on Biomedical Imaging). https://doi.org/10.1109/ISBI.2013.6556490