Lamin A/C gene and a related sequence map to human chromosomes 1q12.1-q23 and 10

Asha K. Kamat, Mariano Rocchi, David I Smith, Orlando J. Miller

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Lamins A and C are products of alternate splicing of one transcript from a single gene. We have isolated a partial cDNA, cE1-2, whose 800-bp sequence is 99% identical to the 3′ untranslated region of the lamin A/C gene. We report here the mapping of this gene and a closely related sequence to human chromosomes 1 and 10, more specifically, to 1q12.1-q23. The localization of cE1-2 hybridizing sequences to two different chromosomes suggests that one of these loci represents an as yet unknown member of the lamin gene family, either a pseudogene or an expressed gene.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalSomatic Cell and Molecular Genetics
Volume19
Issue number2
DOIs
StatePublished - Mar 1993
Externally publishedYes

Fingerprint

Lamin Type A
Human Chromosomes
Genes
Lamins
Chromosomes, Human, Pair 10
Pseudogenes
Chromosome Mapping
Chromosomes, Human, Pair 1
Alternative Splicing
3' Untranslated Regions
Complementary DNA
Chromosomes

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

Cite this

Lamin A/C gene and a related sequence map to human chromosomes 1q12.1-q23 and 10. / Kamat, Asha K.; Rocchi, Mariano; Smith, David I; Miller, Orlando J.

In: Somatic Cell and Molecular Genetics, Vol. 19, No. 2, 03.1993, p. 203-208.

Research output: Contribution to journalArticle

Kamat, Asha K. ; Rocchi, Mariano ; Smith, David I ; Miller, Orlando J. / Lamin A/C gene and a related sequence map to human chromosomes 1q12.1-q23 and 10. In: Somatic Cell and Molecular Genetics. 1993 ; Vol. 19, No. 2. pp. 203-208.
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