Lamin A/C gene and a related sequence map to human chromosomes 1q12.1-q23 and 10

Asha K. Kamat, Mariano Rocchi, David I. Smith, Orlando J. Miller

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Lamins A and C are products of alternate splicing of one transcript from a single gene. We have isolated a partial cDNA, cE1-2, whose 800-bp sequence is 99% identical to the 3′ untranslated region of the lamin A/C gene. We report here the mapping of this gene and a closely related sequence to human chromosomes 1 and 10, more specifically, to 1q12.1-q23. The localization of cE1-2 hybridizing sequences to two different chromosomes suggests that one of these loci represents an as yet unknown member of the lamin gene family, either a pseudogene or an expressed gene.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalSomatic Cell and Molecular Genetics
Volume19
Issue number2
DOIs
StatePublished - Mar 1993

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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