Laguna Negra Virus Infection Causes Hantavirus Pulmonary Syndrome in Turkish Hamsters (Mesocricetus brandti)

K. Hardcastle, D. Scott, D. Safronetz, D. L. Brining, Hideki Ebihara, H. Feldmann, R. A. LaCasse

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Laguna Negra virus (LNV) is a New World hantavirus associated with severe and often fatal cardiopulmonary disease in humans, known as hantavirus pulmonary syndrome (HPS). Five hamster species were evaluated for clinical and serologic responses following inoculation with 4 hantaviruses. Of the 5 hamster species, only Turkish hamsters infected with LNV demonstrated signs consistent with HPS and a fatality rate of 43%. Clinical manifestations in infected animals that succumbed to disease included severe and rapid onset of dyspnea, weight loss, leukopenia, and reduced thrombocyte numbers as compared to uninfected controls. Histopathologic examination revealed lung lesions that resemble the hallmarks of HPS in humans, including interstitial pneumonia and pulmonary edema, as well as generalized infection of endothelial cells and macrophages in major organ tissues. Histologic lesions corresponded to the presence of viral antigen in affected tissues. To date, there have been no small animal models available to study LNV infection and pathogenesis. The Turkish hamster model of LNV infection may be important in the study of LNV-induced HPS pathogenesis and development of disease treatment and prevention strategies.

Original languageEnglish (US)
Pages (from-to)182-189
Number of pages8
JournalVeterinary Pathology
Volume53
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • hantavirus
  • hantavirus pulmonary syndrome
  • interstitial pneumonia
  • Laguna Negra virus
  • lungs
  • Mesocricetus brandti
  • pulmonary edema
  • Turkish hamsters

ASJC Scopus subject areas

  • veterinary(all)

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