Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist

Chemical Compounds

• Secretin 100%
• Agent Interacting With Transmitter, Hormone or Drug Receptor 72%
• Lactam 71%
• Peptide 37%
• Antagonist 13%
• Molecular Mechanic 7%
• Kd 5%
• Molecular Dynamics 5%
• Simulation 4%

Medicine & Life Sciences

• Lactams 93%
• Secretin 82%
• Peptides 41%
• Ligands 23%
• secretin receptor 13%
• Peptide Receptors 10%
• Molecular Dynamics Simulation 9%
• Disulfides 8%
• Mechanics 8%
• G-Protein-Coupled Receptors 8%