Lack of susceptibility to ischemic necrosis of the remnant liver following partial hepatectomy in the rat

K. Watt, K. Kives, I. Corbin, M. Zhang, G. Y. Minuk

Research output: Contribution to journalArticle

Abstract

Background/Aims: The increase in liver lobule dimensions that occurs following partial hepatectomy could predispose living related donors to ischemic hepatic injury were shock-like states to occur in the future. Methodology: In the present study, rats that had undergone 70% partial hepatectomies or sham surgery six weeks earlier were progressively bled to a maximum of 40% total circulating blood volume. Results: Despite significant increases in liver lobule dimensions (1.5x controls), hepatectomized rats did not manifest biochemical or histologic evidence of early or more extensive hepatic injury when compared to sham-operated controls. Conclusions: The results of this study suggest that despite theoretical concerns, living related donors are not predisposed to develop ischemic hepatic injury were shock-like states to develop in the future.

Original languageEnglish (US)
Pages (from-to)463-465
Number of pages3
JournalHepato-Gastroenterology
Volume54
Issue number74
StatePublished - Mar 1 2007

Keywords

  • Hepatitic
  • Ischemic hepatitis
  • Liver
  • Liver disease
  • Liver failure
  • Liver transplantation
  • Living related donor
  • Shock liver

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Watt, K., Kives, K., Corbin, I., Zhang, M., & Minuk, G. Y. (2007). Lack of susceptibility to ischemic necrosis of the remnant liver following partial hepatectomy in the rat. Hepato-Gastroenterology, 54(74), 463-465.