Lack of sedation: Fatal Forty DDI: Midazolam, carbamazepine interaction, CYP3A4

Erica D. Wittwer, Juraj Sprung, Wayne T. Nicholson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This case discusses a pharmacokinetic interaction between midazolam and carbamazepine. Midazolam is a cytochrome P450 3A4 substrate and carbamazepine is a 3A4 inducer. Coadministration signifi cantly decreases the sedative effects of oral midazolam.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Pages369-372
Number of pages4
ISBN (Print)9781461474951, 9781461474944
DOIs
StatePublished - Sep 15 2015

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wittwer, E. D., Sprung, J., & Nicholson, W. T. (2015). Lack of sedation: Fatal Forty DDI: Midazolam, carbamazepine interaction, CYP3A4. In A Case Approach to Perioperative Drug-Drug Interactions (pp. 369-372). Springer New York. https://doi.org/10.1007/978-1-4614-7495-1_78