Lack of FDG uptake in small cell carcinoma associated with ANNA-1 positive paraneoplastic autonomic neuropathy

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

A 76-year-old smoker presented with profound weight loss due to gastrointestinal dysmotility associated with high levels of the paraneoplastic antibody ANNA-1. Serial computed tomography scans showed regressing subcarinal adenopathy, and positron emission tomography imaging showed mild fluorodeoxy-d-glucose uptake in subcarinal nodes, suggestive of benign disease. Diagnosis of small cell carcinoma was established by biopsy of mediastinal nodes. This case highlights the importance of a thorough search for malignancy in patients with high levels of circulating autoantibodies and suggests that benign-appearing imaging studies be interpreted with caution in patients with paraneoplastic autoimmune syndromes.

Original languageEnglish (US)
Pages (from-to)542-544
Number of pages3
JournalJournal of Thoracic Oncology
Volume3
Issue number5
DOIs
StatePublished - May 2008

Keywords

  • ANNA-1
  • Autoimmune
  • PET
  • Paraneoplastic
  • Small cell cancer

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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