Lack of evidence for hepatitis B virus (HBV) infection in fulminant non-A, non-B hepatitis

Tomasz Laskus, Jorge Rakela, Russel H. Wiesner, Jeffery L. Steers, David H. Persing

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We studied eight patients who had orthotopic liver transplantation for fulminant hepatic failure in the course of acute non-A, non-B hepatitis. HBV DNA was searched for extensively in the liver tissue by PCR using several sets of primers in conventional and heminested reactions. All patients were negative for HBV DNA in liver tissue by all assays employed; furthermore, they were negative for HEV RNA, HCV RNA, and HBV DNA in serum. Although the causative role of HEV and HCV in fulminant non-A, non-B hepatitis cannot be excluded, our data do not support a causative association between this syndrome and HBV infection.

Original languageEnglish (US)
Pages (from-to)1677-1682
Number of pages6
JournalDigestive diseases and sciences
Volume39
Issue number8
DOIs
StatePublished - Aug 1994

Keywords

  • HBV
  • fulminant hepatitis
  • non-A
  • non-B hepatitis

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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