Lack of effect of indomethacin on glomerular filtration rate after release of 24 hour ureteral obstruction in the rat

The hypothesis was tested that treatment with indomethacin would attenuate the marked decrease in glomerular filtration rate (GFR) observed following release of 24-hour unilateral ureteral obstruction in the rat. Clearance studies were performed on 15 rats which were pretreated with indomethacin (10 mg/kg/day) and on 12 control rats which received the indomethacin vehicle alone. The GFRs of the postobstructed kidneys were 0.26 ± 0.05 ml/min and 0.21 ± 0.04 ml/min for the indomethacin-treated and control rats, respectively, markedly less than the GFRs of the contralateral kidneys. We conclude that the marked decrease in GRF following release of 24-hour ureteral occlusion is not significantly affected by indomethacin pretreatment.