Lack of effect of indomethacin on glomerular filtration rate after release of 24 hour ureteral obstruction in the rat

Brooks Sayre Edwards, G. R. Marchand, W. S. Spielman

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Abstract

The hypothesis was tested that treatment with indomethacin would attenuate the marked decrease in glomerular filtration rate (GFR) observed following release of 24-hour unilateral ureteral obstruction in the rat. Clearance studies were performed on 15 rats which were pretreated with indomethacin (10 mg/kg/day) and on 12 control rats which received the indomethacin vehicle alone. The GFRs of the postobstructed kidneys were 0.26 ± 0.05 ml/min and 0.21 ± 0.04 ml/min for the indomethacin-treated and control rats, respectively, markedly less than the GFRs of the contralateral kidneys. We conclude that the marked decrease in GRF following release of 24-hour ureteral occlusion is not significantly affected by indomethacin pretreatment.

Original languageEnglish (US)
Pages (from-to)166-171
Number of pages6
JournalMineral and Electrolyte Metabolism
Volume1
Issue number3
StatePublished - 1978

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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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