The hypothesis was tested that treatment with indomethacin would attenuate the marked decrease in glomerular filtration rate (GFR) observed following release of 24-hour unilateral ureteral obstruction in the rat. Clearance studies were performed on 15 rats which were pretreated with indomethacin (10 mg/kg/day) and on 12 control rats which received the indomethacin vehicle alone. The GFRs of the postobstructed kidneys were 0.26 ± 0.05 ml/min and 0.21 ± 0.04 ml/min for the indomethacin-treated and control rats, respectively, markedly less than the GFRs of the contralateral kidneys. We conclude that the marked decrease in GRF following release of 24-hour ureteral occlusion is not significantly affected by indomethacin pretreatment.
|Original language||English (US)|
|Number of pages||6|
|Journal||Mineral and Electrolyte Metabolism|
|State||Published - 1978|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism