Lack of effect of hyperglycemia on lipolysis in humans

M. Caruso, G. D. Divertie, Michael Dennis Jensen, J. M. Miles

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Controversy exists regarding whether plasma glucose concentrations are independently involved in the regulation of adipose tissue lipolysis. In the present study, six subjects with insulin-dependent diabetes and six nondiabetic volunteers were studied during infusion of somatostatin, growth hormone, and insulin at rates designed to maintain basal rates of lipolysis, which was traced using a constant infusion of [1-14C]palmitate. A euglycemic (~ 5 mmol/l) clamp was performed for 3 h, followed by 3 h of hyperglycemia (~ 9 and ~ 11 mmol/l in nondiabetic and diabetic subjects, respectively). Ten nondiabetic subjects were studied during 6 h of euglycemia to exclude time-dependent changes in lipolysis. The results showed that palmitate concentrations did not change between euglycemia and hyperglycemia in either group [118 ± 10 vs. 132 ± 14 μmol/l and 145 ± 21 vs. 134 ± 15 μmol/l in nondiabetic and diabetic subjects, respectively; both P = not significant (NS)]. Similarly, palmitate rate of appearance (R(a)) did not change during hyperglycemia (1.0 ± 0.1 and 1.7 ± 0.4 μmol · kg-1 · min-1 in nondiabetic and diabetic subjects, respectively) compared with euglycemia (1.0 ± 0.1 and 1.6 ± 0.4 μmol · kg-1 · min-1 in nondiabetic and diabetic subjects, respectively; P = NS). Palmitate concentrations and R(a) did not change during 6 h of euglycemia in nondiabetic volunteers. Thus hyperglycemia per se has no effect on free fatty acid turnover. Changes in lipolysis that occur coincident with hyperglycemia are probably due to changes in other circulating substrates or hormones known to affect lipolysis.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume259
Issue number4 22-4
StatePublished - 1990

Fingerprint

Lipolysis
Hyperglycemia
Palmitates
Volunteers
Insulin
Clamping devices
Medical problems
Somatostatin
Nonesterified Fatty Acids
Growth Hormone
Adipose Tissue
Hormones
Tissue
Plasmas
Glucose
Substrates

Keywords

  • free fatty acids
  • insulin-dependent diabetes
  • kinetics

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology

Cite this

Lack of effect of hyperglycemia on lipolysis in humans. / Caruso, M.; Divertie, G. D.; Jensen, Michael Dennis; Miles, J. M.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 259, No. 4 22-4, 1990.

Research output: Contribution to journalArticle

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