Lack of correlation between cerebrospinal fluid thyrotropin-releasing hormone (TRH) and TRH-stimulated thyroid-stimulating hormone in patients with depression

Mark A Frye, Robert T. Dunn, Keith A. Gary, Timothy A. Kimbrell, Ann M. Callahan, David A. Luckenbaugh, Gabriela Corá-Locatelli, Elizabeth Vanderham, Andrew Winokur, Robert M. Post

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: It has been proposed that elevated central thyrotropin- releasing hormone (TRH) is associated with the blunted thyroid-stimulating hormone (TSH) response to TRH in patients with depression. Few studies have directly evaluated this relationship between central nervous system and peripheral endocrine systems in the same patient population. Methods: 15 depressed patients (4 male, 11 female, 12 bipolar, and 3 unipolar) during a double-blind, medication-free period of at least 2 weeks duration, underwent a baseline lumbar puncture followed by a TRH stimulation test. Cerebrospinal fluid (CSF) TRH and serial serum TSH, free thyroxine, triiodothyronine, prolactin, and cortisol were measured. A blunted response to TRH was defined as a delta TSH less than 7 μU/mL. Results: There was no significant difference in mean CSF TRH between 'blunters' (2.82 ± 1.36 pg/mL) and 'nonblunters' (3.97 ± 0.62 pg/mL, p = .40). There was no evidence of an inverse relationship between CSF TRH and baseline or delta TSH. There was no correlation between CSF TRH and the severity of depression or any other endocrine measure. Conclusions: These data are not consistent with the prediction of hypothalamic TRH hypersecretion and subsequent pituitary down- regulation in depression; however, CSF TRH may be from a nonparaventricular nucleus-hypothalamic source (i.e., limbic area, suprachiasmatic nucleus, brain stem-dorsal raphe) and thus, not necessarily related to peripheral neuroendocrine indices.

Original languageEnglish (US)
Pages (from-to)1049-1052
Number of pages4
JournalBiological Psychiatry
Volume45
Issue number8
DOIs
StatePublished - Apr 15 1999
Externally publishedYes

Fingerprint

Thyrotropin-Releasing Hormone
Thyrotropin
Cerebrospinal Fluid
Pituitary Hormone-Releasing Hormones
Suprachiasmatic Nucleus
Endocrine System
Spinal Puncture
Triiodothyronine
Thyroxine
Prolactin
Brain Stem
Hydrocortisone
Down-Regulation
Central Nervous System

Keywords

  • Cerebrospinal fluid
  • Depression
  • Thyroid-stimulating hormone
  • Thyrotropin-releasing hormone

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Lack of correlation between cerebrospinal fluid thyrotropin-releasing hormone (TRH) and TRH-stimulated thyroid-stimulating hormone in patients with depression. / Frye, Mark A; Dunn, Robert T.; Gary, Keith A.; Kimbrell, Timothy A.; Callahan, Ann M.; Luckenbaugh, David A.; Corá-Locatelli, Gabriela; Vanderham, Elizabeth; Winokur, Andrew; Post, Robert M.

In: Biological Psychiatry, Vol. 45, No. 8, 15.04.1999, p. 1049-1052.

Research output: Contribution to journalArticle

Frye, MA, Dunn, RT, Gary, KA, Kimbrell, TA, Callahan, AM, Luckenbaugh, DA, Corá-Locatelli, G, Vanderham, E, Winokur, A & Post, RM 1999, 'Lack of correlation between cerebrospinal fluid thyrotropin-releasing hormone (TRH) and TRH-stimulated thyroid-stimulating hormone in patients with depression', Biological Psychiatry, vol. 45, no. 8, pp. 1049-1052. https://doi.org/10.1016/S0006-3223(98)00322-9
Frye, Mark A ; Dunn, Robert T. ; Gary, Keith A. ; Kimbrell, Timothy A. ; Callahan, Ann M. ; Luckenbaugh, David A. ; Corá-Locatelli, Gabriela ; Vanderham, Elizabeth ; Winokur, Andrew ; Post, Robert M. / Lack of correlation between cerebrospinal fluid thyrotropin-releasing hormone (TRH) and TRH-stimulated thyroid-stimulating hormone in patients with depression. In: Biological Psychiatry. 1999 ; Vol. 45, No. 8. pp. 1049-1052.
@article{f6f7e543e3794a889a1f331a1df8d4bc,
title = "Lack of correlation between cerebrospinal fluid thyrotropin-releasing hormone (TRH) and TRH-stimulated thyroid-stimulating hormone in patients with depression",
abstract = "Background: It has been proposed that elevated central thyrotropin- releasing hormone (TRH) is associated with the blunted thyroid-stimulating hormone (TSH) response to TRH in patients with depression. Few studies have directly evaluated this relationship between central nervous system and peripheral endocrine systems in the same patient population. Methods: 15 depressed patients (4 male, 11 female, 12 bipolar, and 3 unipolar) during a double-blind, medication-free period of at least 2 weeks duration, underwent a baseline lumbar puncture followed by a TRH stimulation test. Cerebrospinal fluid (CSF) TRH and serial serum TSH, free thyroxine, triiodothyronine, prolactin, and cortisol were measured. A blunted response to TRH was defined as a delta TSH less than 7 μU/mL. Results: There was no significant difference in mean CSF TRH between 'blunters' (2.82 ± 1.36 pg/mL) and 'nonblunters' (3.97 ± 0.62 pg/mL, p = .40). There was no evidence of an inverse relationship between CSF TRH and baseline or delta TSH. There was no correlation between CSF TRH and the severity of depression or any other endocrine measure. Conclusions: These data are not consistent with the prediction of hypothalamic TRH hypersecretion and subsequent pituitary down- regulation in depression; however, CSF TRH may be from a nonparaventricular nucleus-hypothalamic source (i.e., limbic area, suprachiasmatic nucleus, brain stem-dorsal raphe) and thus, not necessarily related to peripheral neuroendocrine indices.",
keywords = "Cerebrospinal fluid, Depression, Thyroid-stimulating hormone, Thyrotropin-releasing hormone",
author = "Frye, {Mark A} and Dunn, {Robert T.} and Gary, {Keith A.} and Kimbrell, {Timothy A.} and Callahan, {Ann M.} and Luckenbaugh, {David A.} and Gabriela Cor{\'a}-Locatelli and Elizabeth Vanderham and Andrew Winokur and Post, {Robert M.}",
year = "1999",
month = "4",
day = "15",
doi = "10.1016/S0006-3223(98)00322-9",
language = "English (US)",
volume = "45",
pages = "1049--1052",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "8",

}

TY - JOUR

T1 - Lack of correlation between cerebrospinal fluid thyrotropin-releasing hormone (TRH) and TRH-stimulated thyroid-stimulating hormone in patients with depression

AU - Frye, Mark A

AU - Dunn, Robert T.

AU - Gary, Keith A.

AU - Kimbrell, Timothy A.

AU - Callahan, Ann M.

AU - Luckenbaugh, David A.

AU - Corá-Locatelli, Gabriela

AU - Vanderham, Elizabeth

AU - Winokur, Andrew

AU - Post, Robert M.

PY - 1999/4/15

Y1 - 1999/4/15

N2 - Background: It has been proposed that elevated central thyrotropin- releasing hormone (TRH) is associated with the blunted thyroid-stimulating hormone (TSH) response to TRH in patients with depression. Few studies have directly evaluated this relationship between central nervous system and peripheral endocrine systems in the same patient population. Methods: 15 depressed patients (4 male, 11 female, 12 bipolar, and 3 unipolar) during a double-blind, medication-free period of at least 2 weeks duration, underwent a baseline lumbar puncture followed by a TRH stimulation test. Cerebrospinal fluid (CSF) TRH and serial serum TSH, free thyroxine, triiodothyronine, prolactin, and cortisol were measured. A blunted response to TRH was defined as a delta TSH less than 7 μU/mL. Results: There was no significant difference in mean CSF TRH between 'blunters' (2.82 ± 1.36 pg/mL) and 'nonblunters' (3.97 ± 0.62 pg/mL, p = .40). There was no evidence of an inverse relationship between CSF TRH and baseline or delta TSH. There was no correlation between CSF TRH and the severity of depression or any other endocrine measure. Conclusions: These data are not consistent with the prediction of hypothalamic TRH hypersecretion and subsequent pituitary down- regulation in depression; however, CSF TRH may be from a nonparaventricular nucleus-hypothalamic source (i.e., limbic area, suprachiasmatic nucleus, brain stem-dorsal raphe) and thus, not necessarily related to peripheral neuroendocrine indices.

AB - Background: It has been proposed that elevated central thyrotropin- releasing hormone (TRH) is associated with the blunted thyroid-stimulating hormone (TSH) response to TRH in patients with depression. Few studies have directly evaluated this relationship between central nervous system and peripheral endocrine systems in the same patient population. Methods: 15 depressed patients (4 male, 11 female, 12 bipolar, and 3 unipolar) during a double-blind, medication-free period of at least 2 weeks duration, underwent a baseline lumbar puncture followed by a TRH stimulation test. Cerebrospinal fluid (CSF) TRH and serial serum TSH, free thyroxine, triiodothyronine, prolactin, and cortisol were measured. A blunted response to TRH was defined as a delta TSH less than 7 μU/mL. Results: There was no significant difference in mean CSF TRH between 'blunters' (2.82 ± 1.36 pg/mL) and 'nonblunters' (3.97 ± 0.62 pg/mL, p = .40). There was no evidence of an inverse relationship between CSF TRH and baseline or delta TSH. There was no correlation between CSF TRH and the severity of depression or any other endocrine measure. Conclusions: These data are not consistent with the prediction of hypothalamic TRH hypersecretion and subsequent pituitary down- regulation in depression; however, CSF TRH may be from a nonparaventricular nucleus-hypothalamic source (i.e., limbic area, suprachiasmatic nucleus, brain stem-dorsal raphe) and thus, not necessarily related to peripheral neuroendocrine indices.

KW - Cerebrospinal fluid

KW - Depression

KW - Thyroid-stimulating hormone

KW - Thyrotropin-releasing hormone

UR - http://www.scopus.com/inward/record.url?scp=0033560685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033560685&partnerID=8YFLogxK

U2 - 10.1016/S0006-3223(98)00322-9

DO - 10.1016/S0006-3223(98)00322-9

M3 - Article

VL - 45

SP - 1049

EP - 1052

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 8

ER -