Lack of association of HLA-A and B locus antigens in relapsing polychondritis

H. S. Luthra, C. H. McKenna, P. I. Terasaki

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Relapsing polychondritis is a systemic disease of unknown cause in which various inflammatory reactions recur in the cartilage structures of the ears, nose, and trachea (Kaye & Sones 1964). Although the cause of this disease is unknown, several immunologic abnormalities have been noted which explain some of the pathogenic mechanisms involved (Dolan et al. 1966, Herman & Dennis 1973, Rajapakse & Bywaters 1974, McKenna et al. 1976, Bergfeld 1978, Foidart et al. 1978). To ascertain if the frequency of HLA antigen is increased among patients with this disease, we performed HLA-A and HLA-B locus typing in Caucasian patients with well documented disease. serologically defined HLA antigens at the A and B loci were determined by the microcytotoxicity assay of Mittal et al. (1968). No statistically significant increase in the frequency of any of the HLA-A or B locus antigen type was found between the patient group and the control group. These findings suggest that no correlation exists between HLA-A and B locus antigens and relapsing polychondritis. HLA-DRw antigen typing was not done, although such typing would be of interest.

Original languageEnglish (US)
Pages (from-to)442-443
Number of pages2
JournalTissue Antigens
Volume17
Issue number4
StatePublished - 1981

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Relapsing Polychondritis
HLA-A Antigens
HLA-B Antigens
Antigens
HLA Antigens
Ear Cartilage
Trachea
Nose
Control Groups

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Luthra, H. S., McKenna, C. H., & Terasaki, P. I. (1981). Lack of association of HLA-A and B locus antigens in relapsing polychondritis. Tissue Antigens, 17(4), 442-443.

Lack of association of HLA-A and B locus antigens in relapsing polychondritis. / Luthra, H. S.; McKenna, C. H.; Terasaki, P. I.

In: Tissue Antigens, Vol. 17, No. 4, 1981, p. 442-443.

Research output: Contribution to journalArticle

Luthra, HS, McKenna, CH & Terasaki, PI 1981, 'Lack of association of HLA-A and B locus antigens in relapsing polychondritis', Tissue Antigens, vol. 17, no. 4, pp. 442-443.
Luthra, H. S. ; McKenna, C. H. ; Terasaki, P. I. / Lack of association of HLA-A and B locus antigens in relapsing polychondritis. In: Tissue Antigens. 1981 ; Vol. 17, No. 4. pp. 442-443.
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