TY - JOUR
T1 - Lack of activation of molecular forms of the BNP system in human grade 1 hypertension and relationship to cardiac hypertrophy
AU - Belluardo, Paola
AU - Cataliotti, Alessandro
AU - Bonaiuto, Lorena
AU - Giuffré, Eliana
AU - Maugeri, Egle
AU - Noto, Paola
AU - Orlando, Giovanna
AU - Raspa, Giuseppa
AU - Piazza, Brigida
AU - Babuin, Luciano
AU - Chen, Horng H.
AU - Martin, Fernando L.
AU - McKie, Paul M.
AU - Heublein, Denise M.
AU - Burnett, John C.
AU - Malatino, Lorenzo S.
PY - 2006
Y1 - 2006
N2 - We evaluated relationships among two circulating molecular forms of brain natriuretic peptide (BNP32 and NT-proBNP), severity of hypertension (HTN), and cardiac hypertrophy in subjects with mild, moderate, and severe HTN. We prospectively studied 78 patients (43 males; mean age 51.4 ± 11 yr) with essential HTN and 28 age- and sex-matched controls. BNP32 and NT-proBNP were measured by radioimmunoassay. In grade 1 HTN, BNP32 was not elevated and NT-proBNP was reduced (P = 0.030) compared with controls. However, log-transformed values of BNP32 and NT-proBNP were both increased with severity of HTN from grade 1 to 3 (P <0.0001 and P = 0.003, respectively). By multivariate analysis, log BNP32 was independently predicted by age (β = 0.210, P = 0.026) and HTN grade (β = 0.274, P = 0.004), whereas log NT-proBNP was independently predicted by sex (β = 0.235, P = 0.012) and HTN grade (β = 0.218, P = 0.0023). Two forms of BNP were measured in normal subjects and patients with essential HTN. In grade 1 HTN, BNP32 was unchanged and NT-proBNP was significantly reduced compared with controls. As severity increased in humans with grade 1 to 3 HTN, both BNP32 and NT-proBNP levels were increased while not being affected by the presence of left ventricular hypertrophy. The lack of activation of BNP32 together with the reduction of NT-proBNP in grade 1 HTN may represent an impaired response of the BNP system in the early phase of HTN. The later activation of both forms of BNP may be a late compensatory effect, because it correlates with severity of HTN rather than cardiac hypertrophy/remodeling.
AB - We evaluated relationships among two circulating molecular forms of brain natriuretic peptide (BNP32 and NT-proBNP), severity of hypertension (HTN), and cardiac hypertrophy in subjects with mild, moderate, and severe HTN. We prospectively studied 78 patients (43 males; mean age 51.4 ± 11 yr) with essential HTN and 28 age- and sex-matched controls. BNP32 and NT-proBNP were measured by radioimmunoassay. In grade 1 HTN, BNP32 was not elevated and NT-proBNP was reduced (P = 0.030) compared with controls. However, log-transformed values of BNP32 and NT-proBNP were both increased with severity of HTN from grade 1 to 3 (P <0.0001 and P = 0.003, respectively). By multivariate analysis, log BNP32 was independently predicted by age (β = 0.210, P = 0.026) and HTN grade (β = 0.274, P = 0.004), whereas log NT-proBNP was independently predicted by sex (β = 0.235, P = 0.012) and HTN grade (β = 0.218, P = 0.0023). Two forms of BNP were measured in normal subjects and patients with essential HTN. In grade 1 HTN, BNP32 was unchanged and NT-proBNP was significantly reduced compared with controls. As severity increased in humans with grade 1 to 3 HTN, both BNP32 and NT-proBNP levels were increased while not being affected by the presence of left ventricular hypertrophy. The lack of activation of BNP32 together with the reduction of NT-proBNP in grade 1 HTN may represent an impaired response of the BNP system in the early phase of HTN. The later activation of both forms of BNP may be a late compensatory effect, because it correlates with severity of HTN rather than cardiac hypertrophy/remodeling.
KW - Amino-terminal pro-brain natriuretic peptide
KW - Brain natriuretic peptide
KW - Left ventricular hypertrophy
KW - Natriuretic peptide
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U2 - 10.1152/ajpheart.00107.2006
DO - 10.1152/ajpheart.00107.2006
M3 - Article
C2 - 16648193
AN - SCOPUS:33749352356
SN - 0363-6135
VL - 291
SP - H1529-H1535
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
IS - 4
ER -