KATP channel polymorphism is associated with left ventricular size in hypertensive individuals: A large-scale community-based study

Santiago Reyes; Andre Terzic; Douglas W. Mahoney; Margaret M. Redfield; Richard J. Rodeheffer; Timothy M. Olson

doi:10.1007/s00439-008-0519-3

K_ATP channel polymorphism is associated with left ventricular size in hypertensive individuals: A large-scale community-based study

Santiago Reyes, Andre Terzic, Douglas W. Mahoney, Margaret M. Redfield, Richard J. Rodeheffer, Timothy M. Olson

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

ATP-sensitive K⁺ (K_ATP) channel mutations have been identified in individuals with dilated cardiomyopathy and overt heart failure. Here, a common E23K functional polymorphism in the Kir6.2 channel pore versus cardiac phenotype was studied in a cross-sectional community-based cohort (n = 2,031). The KK genotype was associated with greater left ventricular size among subjects with increased stress load due to hypertension. These findings implicate Kir6.2 K23 as a risk factor for adverse subclinical myocardial remodeling, and underscore the significance of cardiac K_ATP channels within the population.

Original language	English (US)
Pages (from-to)	665-667
Number of pages	3
Journal	Human genetics
Volume	123
Issue number	6
DOIs	https://doi.org/10.1007/s00439-008-0519-3
State	Published - Jul 2008

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "KATP channel polymorphism is associated with left ventricular size in hypertensive individuals: A large-scale community-based study",

abstract = "ATP-sensitive K+ (KATP) channel mutations have been identified in individuals with dilated cardiomyopathy and overt heart failure. Here, a common E23K functional polymorphism in the Kir6.2 channel pore versus cardiac phenotype was studied in a cross-sectional community-based cohort (n = 2,031). The KK genotype was associated with greater left ventricular size among subjects with increased stress load due to hypertension. These findings implicate Kir6.2 K23 as a risk factor for adverse subclinical myocardial remodeling, and underscore the significance of cardiac KATP channels within the population.",

author = "Santiago Reyes and Andre Terzic and Mahoney, {Douglas W.} and Redfield, {Margaret M.} and Rodeheffer, {Richard J.} and Olson, {Timothy M.}",

note = "Funding Information: Acknowledgments This work was supported by the National Institutes of Health (HL071225, HL064822, and HL55502), Marriott Heart Disease Research Program, and Mayo Graduate School.",

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doi = "10.1007/s00439-008-0519-3",

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T1 - KATP channel polymorphism is associated with left ventricular size in hypertensive individuals

T2 - A large-scale community-based study

AU - Reyes, Santiago

AU - Terzic, Andre

AU - Mahoney, Douglas W.

AU - Redfield, Margaret M.

AU - Rodeheffer, Richard J.

AU - Olson, Timothy M.

N1 - Funding Information: Acknowledgments This work was supported by the National Institutes of Health (HL071225, HL064822, and HL55502), Marriott Heart Disease Research Program, and Mayo Graduate School.

PY - 2008/7

Y1 - 2008/7

N2 - ATP-sensitive K+ (KATP) channel mutations have been identified in individuals with dilated cardiomyopathy and overt heart failure. Here, a common E23K functional polymorphism in the Kir6.2 channel pore versus cardiac phenotype was studied in a cross-sectional community-based cohort (n = 2,031). The KK genotype was associated with greater left ventricular size among subjects with increased stress load due to hypertension. These findings implicate Kir6.2 K23 as a risk factor for adverse subclinical myocardial remodeling, and underscore the significance of cardiac KATP channels within the population.

AB - ATP-sensitive K+ (KATP) channel mutations have been identified in individuals with dilated cardiomyopathy and overt heart failure. Here, a common E23K functional polymorphism in the Kir6.2 channel pore versus cardiac phenotype was studied in a cross-sectional community-based cohort (n = 2,031). The KK genotype was associated with greater left ventricular size among subjects with increased stress load due to hypertension. These findings implicate Kir6.2 K23 as a risk factor for adverse subclinical myocardial remodeling, and underscore the significance of cardiac KATP channels within the population.

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K_ATP channel polymorphism is associated with left ventricular size in hypertensive individuals: A large-scale community-based study

Abstract

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