KATP channel polymorphism is associated with left ventricular size in hypertensive individuals: A large-scale community-based study

Santiago Reyes, Andre Terzic, Douglas W. Mahoney, Margaret May Redfield, Richard J. Rodeheffer, Timothy Mark Olson

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

ATP-sensitive K+ (KATP) channel mutations have been identified in individuals with dilated cardiomyopathy and overt heart failure. Here, a common E23K functional polymorphism in the Kir6.2 channel pore versus cardiac phenotype was studied in a cross-sectional community-based cohort (n = 2,031). The KK genotype was associated with greater left ventricular size among subjects with increased stress load due to hypertension. These findings implicate Kir6.2 K23 as a risk factor for adverse subclinical myocardial remodeling, and underscore the significance of cardiac KATP channels within the population.

Original languageEnglish (US)
Pages (from-to)665-667
Number of pages3
JournalHuman Genetics
Volume123
Issue number6
DOIs
StatePublished - Jul 2008

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KATP Channels
Dilated Cardiomyopathy
Heart Failure
Adenosine Triphosphate
Genotype
Hypertension
Phenotype
Mutation
Population
Kir6.2 channel

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

KATP channel polymorphism is associated with left ventricular size in hypertensive individuals : A large-scale community-based study. / Reyes, Santiago; Terzic, Andre; Mahoney, Douglas W.; Redfield, Margaret May; Rodeheffer, Richard J.; Olson, Timothy Mark.

In: Human Genetics, Vol. 123, No. 6, 07.2008, p. 665-667.

Research output: Contribution to journalArticle

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