KATP channel polymorphism is associated with left ventricular size in hypertensive individuals: A large-scale community-based study

Santiago Reyes, Andre Terzic, Douglas W. Mahoney, Margaret M. Redfield, Richard J. Rodeheffer, Timothy M. Olson

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

ATP-sensitive K+ (KATP) channel mutations have been identified in individuals with dilated cardiomyopathy and overt heart failure. Here, a common E23K functional polymorphism in the Kir6.2 channel pore versus cardiac phenotype was studied in a cross-sectional community-based cohort (n = 2,031). The KK genotype was associated with greater left ventricular size among subjects with increased stress load due to hypertension. These findings implicate Kir6.2 K23 as a risk factor for adverse subclinical myocardial remodeling, and underscore the significance of cardiac KATP channels within the population.

Original languageEnglish (US)
Pages (from-to)665-667
Number of pages3
JournalHuman genetics
Volume123
Issue number6
DOIs
StatePublished - Jul 2008

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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