KATP channel pharmacogenomics: From bench to bedside

S. Sattiraju, S. Reyes, G. C. Kane, A. Terzic

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Inheritance plays a significant role in defining drug response and toxicity. Advances in molecular pharmacology and modern genomics emphasize genetic variation in dictating inter-individual pharmacokinetics and pharmacodynamics. A case in point is the homeostatic ATP-sensitive potassium (KATP) channel, an established drug target that adjusts membrane excitability to match cellular energetic demand. There is an increased recognition that genetic variability of the KATP channel impacts therapeutic decision-making in human disease.

Original languageEnglish (US)
Pages (from-to)354-357
Number of pages4
JournalClinical pharmacology and therapeutics
Volume83
Issue number2
DOIs
StatePublished - Feb 2008

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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