TY - JOUR
T1 - KATP channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation
AU - Olson, T. M.
AU - Alekseev, A. E.
AU - Moreau, C.
AU - Liu, X. K.
AU - Zingman, L. V.
AU - Asirvatham, S. J.
AU - Jahangir, A.
AU - Terzic, A.
AU - Miki, T.
PY - 2007/2
Y1 - 2007/2
N2 - Background: A 53-year-old female presented with a 10-year history of paroxysmal atrial fibrillation (AF), precipitated by activity and refractory to medical therapy. In the absence of traditional risk factors for disease, a genetic defect in electrical homeostasis underlying stress-induced AF was explored. Investigations: Echocardiography, cardiac perfusion stress imaging, invasive electrophysiology with isoproterenol provocation, genomic DNA sequencing of KATP channel genes, exclusion of mutation in 2,000 individuals free of AF, reconstitution of channel defect with molecular phenotyping, and verification of pathogenic link in targeted knockout. Diagnosis: KATP channelopathy caused by missense mutation (Thr1547Ile) of the ABCC9 gene conferring predisposition to adrenergic AF originating from the vein of Marshall. Management: Disruption of arrhythmogenic gene-environment substrate at the vein of Marshall by radiofrequency ablation.
AB - Background: A 53-year-old female presented with a 10-year history of paroxysmal atrial fibrillation (AF), precipitated by activity and refractory to medical therapy. In the absence of traditional risk factors for disease, a genetic defect in electrical homeostasis underlying stress-induced AF was explored. Investigations: Echocardiography, cardiac perfusion stress imaging, invasive electrophysiology with isoproterenol provocation, genomic DNA sequencing of KATP channel genes, exclusion of mutation in 2,000 individuals free of AF, reconstitution of channel defect with molecular phenotyping, and verification of pathogenic link in targeted knockout. Diagnosis: KATP channelopathy caused by missense mutation (Thr1547Ile) of the ABCC9 gene conferring predisposition to adrenergic AF originating from the vein of Marshall. Management: Disruption of arrhythmogenic gene-environment substrate at the vein of Marshall by radiofrequency ablation.
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U2 - 10.1038/ncpcardio0792
DO - 10.1038/ncpcardio0792
M3 - Article
C2 - 17245405
AN - SCOPUS:33846517015
VL - 4
SP - 110
EP - 116
JO - Nature Reviews Cardiology
JF - Nature Reviews Cardiology
SN - 1759-5002
IS - 2
ER -