KRas, ROS and the initiation of pancreatic cancer

Research output: Contribution to journalComment/debatepeer-review

21 Scopus citations

Abstract

Oncogenic mutations of KRAS are the most frequent driver mutations in pancreatic cancer. Expression of an oncogenic allele of KRAS leads to metabolic changes and altered cellular signaling that both can increase the production of intracellular reactive oxygen species (ROS). Increases in ROS have been shown to drive the formation and progression of pancreatic precancerous lesions by upregulating survival and growth factor signaling. A key issue for precancerous and cancer cells is to keep ROS at levels where they are beneficial for tumor development and progression, but below the threshold that leads to induction of senescence or cell death. In KRas-driven neoplasia aberrantly increased ROS levels are therefore balanced by an upregulation of antioxidant genes.

Original languageEnglish (US)
Pages (from-to)38-42
Number of pages5
JournalSmall GTPases
Volume8
Issue number1
DOIs
StatePublished - Jan 2 2017

Keywords

  • KRas
  • PanIN
  • ROS
  • mitochondria
  • oxidative stress
  • pancreatic cancer

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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