Krüppel-like factors (KLFs) are transcription regulatory proteins. Members of this protein family are characterized by a highly conserved C-terminus that has three zinc finger domains that bind to GC-rich sequences in DNA. The N-terminal domains of these proteins contain regulatory regions that can activate or repress transcription in a context-specific manner. KLFs interact with a wide range of co-activators or co-repressors to accomplish their transcription regulatory function. These interactions provide a complex stage for the chromatin dynamics to unfold and regulate diverse biological functions. This chapter focuses on expanding our understanding of molecular mechanisms of transcription regulation by KLFs and their impact on chromatin dynamics.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)