The diagnostic category of rheumatoid arthritis, a syndrome of chronic inflammatory disease of the synovial membrane and of extraarticular tissues, covers a broad spectrum of clinical phenotypes. Here we propose that distinct combinations of disease risk genes produce heterogeneity of rheumatoid disease. Recognition of this genetic and clinical heterogeneity has immediate implications as it provides the opportunity to develop selective therapies for the different variants of disease.
|Translated title of the contribution||Clinical and genetic heterogeneity of rheumatoid arthritis|
|Number of pages||9|
|Journal||Postepy Higieny i Medycyny Doswiadczalnej|
|State||Published - 2000|
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases