Kinetics of 210Pb entry into the endoneurium

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Alteration in the blood-nerve barrier may be of primary importance in the development of experimental lead neuropathy. Using quantitative track autoradiography, we have directly demonstrated that there is a 15-fold increase in the rate of 210Pb accumulation in the endoneurium 70 days after the onset of chronic intoxication. This change in rate coincides with the appearance of edema but occurs later than the previously demonstrated total endoneurial lead accumulation and later than the onset of segmental demyelination suggesting that, in addition to rate of entry, binding within and exit from this compartment are important determinants of endoneurial lead concentration.

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalBrain Research
Volume225
Issue number1
DOIs
StatePublished - Nov 23 1981

Fingerprint

Peripheral Nerves
Blood-Nerve Barrier
Demyelinating Diseases
Autoradiography
Edema
Lead

Keywords

  • Pb
  • endoneurium
  • kinetics

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Kinetics of 210Pb entry into the endoneurium. / Windebank, Anthony John; Dyck, Peter J.

In: Brain Research, Vol. 225, No. 1, 23.11.1981, p. 67-73.

Research output: Contribution to journalArticle

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