Kidney transplantation: Mechanisms of rejection and acceptance

Lynn D. Cornell, R. Neal Smith, Robert B. Colvin

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

We describe the molecular and cellular mechanisms believed to be responsible for the rejection of renal allografts, including acute T cell-mediated rejection, acute antibody-mediated (humoral) rejection, rejection mediated by the innate immune system, and chronic rejection. We present mechanisms of graft acceptance, including accommodation, regulation, and tolerance. Studies in animals have replicated many pathologic features of acute and chronic rejection. We illuminate the pathogenesis of human pathology by reflection from experimental models.

Original languageEnglish (US)
Pages (from-to)189-220
Number of pages32
JournalAnnual Review of Pathology: Mechanisms of Disease
Volume3
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Graft Rejection
Kidney Transplantation
Allografts
Immune System
Theoretical Models
Pathology
T-Lymphocytes
Transplants
Kidney
Antibodies

Keywords

  • Accommodation
  • Acute rejection
  • Antibody
  • Chronic rejection
  • Renal allograft

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Kidney transplantation : Mechanisms of rejection and acceptance. / Cornell, Lynn D.; Smith, R. Neal; Colvin, Robert B.

In: Annual Review of Pathology: Mechanisms of Disease, Vol. 3, 2008, p. 189-220.

Research output: Contribution to journalArticle

Cornell, Lynn D. ; Smith, R. Neal ; Colvin, Robert B. / Kidney transplantation : Mechanisms of rejection and acceptance. In: Annual Review of Pathology: Mechanisms of Disease. 2008 ; Vol. 3. pp. 189-220.
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