Kidney transplantation after previous liver transplantation: Analysis of the organ procurement transplant network database

Thomas A. Gonwa, Maureen A. McBride, Martin Mai, Hani M. Wadei

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Patients after liver transplant have a high incidence of chronic kidney disease and end-stage renal disease (ESRD). We investigated kidney transplantation after liver transplantation using the Organ Procurement Transplant Network database. Methods: The Organ Procurement Transplant Network database was queried for patients who received kidney transplantation after previous liver transplantation. These patients were compared with patients who received primary kidney transplantation alone during the same time period. Results: Between 1997 and 2008, 157,086 primary kidney transplants were performed. Of these, 680 deceased donor kidney transplants and 410 living donor kidney transplants were performed in previous recipients of liver transplants. The number of kidney after liver transplants performed each year has increased from 37 per year to 124 per year in 2008. The time from liver transplant to kidney transplant increased from 8.2 to 9.0 years for living donor transplants and from 5.4 to 9.6 years for deceased donor. The 1, 3, and 5 year actuarial graft survival in both living donor kidney after liver transplant and deceased donor kidney after liver transplant are less than the kidney transplant alone patients. However, the death-censored graft survivals are equal. The patient survival is also less but is similar to what would be expected in liver transplant recipients who did not have ESRD. In 2008, kidney after liver transplantation represented 0.9% of the total kidney alone transplants performed in the United States. CONCLUSION.: Kidney transplantation is an appropriate therapy for selected patients who develop ESRD after liver transplantation.

Original languageEnglish (US)
Pages (from-to)31-35
Number of pages5
JournalTransplantation
Volume92
Issue number1
DOIs
StatePublished - Jul 15 2011

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Tissue and Organ Procurement
Liver Transplantation
Kidney Transplantation
Databases
Transplants
Kidney
Liver
Living Donors
Chronic Kidney Failure
Tissue Donors
Graft Survival
Chronic Renal Insufficiency

Keywords

  • Kidney transplantation
  • Liver transplantation
  • Survival

ASJC Scopus subject areas

  • Transplantation

Cite this

Kidney transplantation after previous liver transplantation : Analysis of the organ procurement transplant network database. / Gonwa, Thomas A.; McBride, Maureen A.; Mai, Martin; Wadei, Hani M.

In: Transplantation, Vol. 92, No. 1, 15.07.2011, p. 31-35.

Research output: Contribution to journalArticle

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